Dachshund homolog 1 (Dach1)
1_MAVPA 6_ ALIPP 11_ TQLVP 16_ PQPPI 21_ STSAS 26_ SSGTT 31_ TSTSS 36_ ATSSP 41_ APSIG 46_ PPASS 51_ GPTLF 56_ RPEPI 61_ ASAAA 66_ AAATV 71_ TSTGG 76_ GGGGG 81_ GSGGG 86_ GGSSG 91_ NGGGG 96_ GGGGG 101_ GSNCN 106_ PNLAA 111_ ASNGS 116_ GGGGG 121_ GISAG 126_ GGVAS 131_ STPIN 136_ ASTGS 141_ SSSSS 146_ SSSSS 151_ SSSSS 156_ SSSSS 161_ SSSCG 166_ PLPGK 171_ PVYST 176_ PSPVE 181_ NTPQN 186_ NECKM 191_ VDLRG 196_ AKVAS 201_ FTVEG 206_ CELIC 211_ LPQAF 216_ DLFLK 221_ HLVGG 226_ LHTVY 231_ TKLKR 236_ LEITP 241_ VVCNV 246_ EQVRI 251_ LRGLG 256_ AIQPG 261_ VNRCK 266_ LISRK 271_ DFETL 276_ YNDCT 281_ NASSR 286_ PGRPP 291_ KRTQS 296_ VTSPE 301_ NSHIM 306_ PHSVP 311_ GLMSP 316_ GIIPP 321_ TGLTA 326_ AAAAA 331_ AAATN 336_ AAIAE 341_ AMKVK 346_ KIKLE 351_ AMSNY 356_ HASNN 361_ QHGAD 366_ SENGD 371_ MNSSV 376_ GSSDG 381_ SWDKE 386_ TLPSS 391_ PSQGP 396_ QASIT 401_ HPRMP 406_ GARSL 411_ PLSHP 416_ LNHLQ 421_ QSHLL 426_ PNGLE 431_ LPFMM 436_ MPHPL 441_ IPVSL 446_ PPASV 451_ TMAMS 456_ QMNHL 461_ STIAN 466_ MAAAA 471_ QVQSP 476_ PSRVE 481_ TSVIK 486_ ERVPD 491_ SPSPA 496_ PSLEE 501_ GRRPG 506_ SHPSS 511_ HRSSS 516_ VSSSP 521_ ARTES 526_ SSDRI 531_ PVHQN 536_ GLSMN 541_ QMLMG 546_ LSPNV 551_ LPGPK 556_ EGDLA 561_ GHDMG 566_ HESKR 571_ MHIEK 576_ DETPL 581_ STPTA 586_ RDSLD 591_ KLSLT 596_ GHGQP 601_ LPPGF 606_ PSPFL 611_ FPDGL 616_ SSIET 621_ LLTNI 626_ QGLLK 631_ VAIDN 636_ ARAQE 641_ KQVQL 646_ EKTEL 651_ KMDFL 656_ REREL 661_ RETLE 666_ KQLAM 671_ EQKNR 676_ AIVQK 681_ RLKKE 686_ KKAKR 691_ KLQEA 696_ LEFET 701_ KRREQ 706_ AEQTL 711_ KQAAS 716_ TDSLR 721_ VLNDS 726_ LTPEI 731_ EADRS 736_ GGRTD 741_ AERTI 746_ QDGRL 751_YLKTT
1: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity)