rRNA methyltransferase 2, mitochondrial (EC 2.1.1.-) (16S rRNA (uridine(1369)-2'-O)-methyltransferase) (16S rRNA [Um1369] 2'-O-methyltransferase) (Protein ftsJ homolog 2)
1_MAGYL 6_ KLVCV 11_ SFQRQ 16_ GFHTV 21_ GSRCK 26_ NRTGA 31_ EHLWL 36_ TRHLR 41_ DPFVK 46_ AAKVE 51_ SYRCR 56_ SAFKL 61_ LEVNE 66_ RHQIL 71_ RPGLR 76_ VLDCG 81_ AAPGA 86_ WSQVA 91_ VQKVN 96_ AAGTD 101_ PSSPV 106_ GFVLG 111_ VDLLH 116_ IFPLE 121_ GATFL 126_ CPADV 131_ TDPRT 136_ SQRIL 141_ EVLPG 146_ RRADV 151_ ILSDM 156_ APNAT 161_ GFRDL 166_ DHDRL 171_ ISLCL 176_ TLLSV 181_ TPDIL 186_ QPGGT 191_ FLCKT 196_ WAGSQ 201_ SRRLQ 206_ RRLTE 211_ EFQNV 216_ RIIKP 221_ EASRK 226_ ESSEV 231_ YFLAT 236_ QYHGR 241_KGTVK
1: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA (PubMed:25009282, PubMed:25074936, PubMed:35177605). This activity may require prior 2'-O-methylguanosine modification at position 1370 (Gm1370) by MRM3 (PubMed:35177605). Essential for late-stage assembly of mtLSU required for efficient translation of mitochondrial DNA encoded proteins; methyltransferase activity is not required for this function (PubMed:35177605). Essential for mitochondrial respiratory function (PubMed:35177605)