Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (REV7 homolog) (hREV7)
1_MTTLT 6_ RQDLN 11_ FGQVV 16_ ADVLC 21_ EFLEV 26_ AVHLI 31_ LYVRE 36_ VYPVG 41_ IFQKR 46_ KKYNV 51_ PVQMS 56_ CHPEL 61_ NQYIQ 66_ DTLHC 71_ VKPLL 76_ EKNDV 81_ EKVVV 86_ VILDK 91_ EHRPV 96_ EKFVF 101_ EITQP 106_ PLLSI 111_ SSDSL 116_ LSHVE 121_ QLLRA 126_ FILKI 131_ SVCDA 136_ VLDHN 141_ PPGCT 146_ FTVLV 151_ HTREA 156_ ATRNM 161_ EKIQV 166_ IKDFP 171_ WILAD 176_ EQDVH 181_ MHDPR 186_ LIPLK 191_ TMTSD 196_ ILKMQ 201_ LYVEE 206_RAHKG
1: Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:17296730, PubMed:17719540, PubMed:19443654, PubMed:29656893). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:20164194). Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194). Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 (PubMed:17296730). Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle (PubMed:11459825, PubMed:17719540). Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (PubMed:19443654)