Exportin-7 (Exp7) (Ran-binding protein 16)
1_MADHV 6_ QSLAQ 11_ LENLC 16_ KQLYE 21_ TTDTT 26_ TRLQA 31_ EKALV 36_ EFTNS 41_ PDCLS 46_ KCQLL 51_ LERGS 56_ SSYSQ 61_ LLAAT 66_ CLTKL 71_ VSRTN 76_ NPLPL 81_ EQRID 86_ IRNYV 91_ LNYLA 96_ TRPKL 101_ ATFVT 106_ QALIQ 111_ LYARI 116_ TKLGW 121_ FDCQK 126_ DDYVF 131_ RNAIT 136_ DVTRF 141_ LQDSV 146_ EYCII 151_ GVTIL 156_ SQLTN 161_ EINQA 166_ DTTHP 171_ LTKHR 176_ KIASS 181_ FRDSS 186_ LFDIF 191_ TLSCN 196_ LLKQA 201_ SGKNL 206_ NLNDE 211_ SQHGL 216_ LMQLL 221_ KLTHN 226_ CLNFD 231_ FIGTS 236_ TDESS 241_ DDLCT 246_ VQIPT 251_ SWRSA 256_ FLDSS 261_ TLQLF 266_ FDLYH 271_ SIPPS 276_ FSPLV 281_ LSCLV 286_ QIASV 291_ RRSLF 296_ NNAER 301_ AKFLS 306_ HLVDG 311_ VKRIL 316_ ENPQS 321_ LSDPN 326_ NYHEF 331_ CRLLA 336_ RLKSN 341_ YQLGE 346_ LVKVE 351_ NYPEV 356_ IRLIA 361_ NFTVT 366_ SLQHW 371_ EFAPN 376_ SVHYL 381_ LSLWQ 386_ RLAAS 391_ VPYVK 396_ ATEPH 401_ MLETY 406_ TPEVT 411_ KAYIT 416_ SRLES 421_ VHIIL 426_ RDGLE 431_ DPLED 436_ TGLVQ 441_ QQLDQ 446_ LSTIG 451_ RCEYE 456_ KTCAL 461_ LVQLF 466_ DQSAQ 471_ SYQEL 476_ LQSAS 481_ ASPMD 486_ IAVQE 491_ GRLTW 496_ LVYII 501_ GAVIG 506_ GRVSF 511_ ASTDE 516_ QDAMD 521_ GELVC 526_ RVLQL 531_ MNLTD 536_ SRLAQ 541_ AGNEK 546_ LELAM 551_ LSFFE 556_ QFRKI 561_ YIGDQ 566_ VQKSS 571_ KLYRR 576_ LSEVL 581_ GLNDE 586_ TMVLS 591_ VFIGK 596_ IITNL 601_ KYWGR 606_ CEPIT 611_ SKTLQ 616_ LLNDL 621_ SIGYS 626_ SVRKL 631_ VKLSA 636_ VQFML 641_ NNHTS 646_ EHFSF 651_ LGINN 656_ QSNLT 661_ DMRCR 666_ TTFYT 671_ ALGRL 676_ LMVDL 681_ GEDED 686_ QYEQF 691_ MLPLT 696_ AAFEA 701_ VAQMF 706_ STNSF 711_ NEQEA 716_ KRTLV 721_ GLVRD 726_ LRGIA 731_ FAFNA 736_ KTSFM 741_ MLFEW 746_ IYPSY 751_ MPILQ 756_ RAIEL 761_ WYHDP 766_ ACTTP 771_ VLKLM 776_ AELVH 781_ NRSQR 786_ LQFDV 791_ SSPNG 796_ ILLFR 801_ ETSKM 806_ ITMYG 811_ NRILT 816_ LGEVP 821_ KDQVY 826_ ALKLK 831_ GISIC 836_ FSMLK 841_ AALSG 846_ SYVNF 851_ GVFRL 856_ YGDDA 861_ LDNAL 866_ QTFIK 871_ LLLSI 876_ PHSDL 881_ LDYPK 886_ LSQSY 891_ YSLLE 896_ VLTQD 901_ HMNFI 906_ ASLEP 911_ HVIMY 916_ ILSSI 921_ SEGLT 926_ ALDTM 931_ VCTGC 936_ CSCLD 941_ HIVTY 946_ LFKQL 951_ SRSTK 956_ KRTTP 961_ LNQES 966_ DRFLH 971_ IMQQH 976_ PEMIQ 981_ QMLST 986_ VLNII 991_ IFEDC 996_ RNQWS 1001_ MSRPL 1006_ LGLIL 1011_ LNEKY 1016_ FSDLR 1021_ NSIVN 1026_ SQPPE 1031_ KQQAM 1036_ HLCFE 1041_ NLMEG 1046_ IERNL 1051_ LTKNR 1056_ DRFTQ 1061_ NLSAF 1066_ RREVN 1071_ DSMKN 1076_ STYGV 1081_NSNDM
1: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus