Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog)
1_MAAAA 6_ AAGPS 11_ PGSGP 16_ GDSPE 21_ GPEGE 26_ APERR 31_ RKAHG 36_ MLKLY 41_ YGLSE 46_ GEAAG 51_ RPAGP 56_ DPLDP 61_ TDLNG 66_ AHFDP 71_ EVYLD 76_ KLRRE 81_ CPLAQ 86_ LMDSE 91_ TDMVR 96_ QIRAL 101_ DSDMQ 106_ TLVYE 111_ NYNKF 116_ ISATD 121_ TIRKM 126_ KNDFR 131_ KMEDE 136_ MDRLA 141_ TNMAV 146_ ITDFS 151_ ARISA 156_ TLQDR 161_ HERIT 166_ KLAGV 171_ HALLR 176_ KLQFL 181_ FELPS 186_ RLTKC 191_ VELGA 196_ YGQAV 201_ RYQGR 206_ AQAVL 211_ QQYQH 216_ LPSFR 221_ AIQDD 226_ CQVIT 231_ ARLAQ 236_ QLRQR 241_ FREGG 246_ SGAPE 251_ QAECV 256_ ELLLA 261_ LGEPA 266_ EELCE 271_ EFLAH 276_ ARGRL 281_ EKELR 286_ NLEAE 291_ LGPSP 296_ PAPDV 301_ LEFTD 306_ HGGSG 311_ FVGGL 316_ CQVAA 321_ AYQEL 326_ FAAQG 331_ PAGAE 336_ KLAAF 341_ ARQLG 346_ SRYFA 351_ LVERR 356_ LAQEQ 361_ GGGDN 366_ SLLVR 371_ ALDRF 376_ HRRLR 381_ APGAL 386_ LAAAG 391_ LADAA 396_ TEIVE 401_ RVARE 406_ RLGHH 411_ LQGLR 416_ AAFLG 421_ CLTDV 426_ RQALA 431_ APRVA 436_ GKEGP 441_ GLAEL 446_ LANVA 451_ SSILS 456_ HIKAS 461_ LAAVH 466_ LFTAK 471_ EVSFS 476_ NKPYF 481_ RGEFC 486_ SQGVR 491_ EGLIV 496_ GFVHS 501_ MCQTA 506_ QSFCD 511_ SPGEK 516_ GGATP 521_ PALLL 526_ LLSRL 531_ CLDYE 536_ TATIS 541_ YILTL 546_ TDEQF 551_ LVQDQ 556_ FPVTP 561_ VSTLC 566_ AEARE 571_ TARRL 576_ LTHYV 581_ KVQGL 586_ VISQM 591_ LRKSV 596_ ETRDW 601_ LSTLE 606_ PRNVR 611_ AVMKR 616_ VVEDT 621_ TAIDV 626_ QVGLL 631_ YEEGV 636_ RKAQS 641_ SDSSK 646_ RTFSV 651_ YSSSR 656_ QQGRY 661_ APSYT 666_ PSAPM 671_ DTNLL 676_ SNIQK 681_ LFSER 686_ IDVFS 691_ PVEFN 696_ KVSVL 701_ TGIIK 706_ ISLKT 711_ LLECV 716_ RLRTF 721_ GRFGL 726_ QQVQV 731_ DCHFL 736_ QLYLW 741_ RFVAD 746_ EELVH 751_ LLLDE 756_ VVASA 761_ ALRCP 766_ DPVPM 771_ EPSVV 776_EVICE
1: Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061)