Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2)
1_MAPLL 6_ GRKPF 11_ PLVKP 16_ LPGEE 21_ PLFTI 26_ PHTQE 31_ AFRTR 36_ EEYEA 41_ RLERY 46_ SERIW 51_ TCKST 56_ GSSQL 61_ THKEA 66_ WEEEQ 71_ EVAEL 76_ LKEEF 81_ PAWYE 86_ KLVLE 91_ MVHHN 96_ TASLE 101_ KLVDT 106_ AWLEI 111_ MTKYA 116_ VGEEC 121_ DFEVG 126_ KEKML 131_ KVKIV 136_ KIHPL 141_ EKVDE 146_ EATEK 151_ KSDGA 156_ CDSPS 161_ SDKEN 166_ SSQIA 171_ QDHQK 176_ KETVV 181_ KEDEG 186_ RRESI 191_ NDRAR 196_ RSPRK 201_ LPTSL 206_ KKGER 211_ KWAPP 216_ KFLPH 221_ KYDVK 226_ LQNED 231_ KIISN 236_ VPADS 241_ LIRTE 246_ RPPNK 251_ EIVRY 256_ FIRHN 261_ ALRAG 266_ TGENA 271_ PWVVE 276_ DELVK 281_ KYSLP 286_ SKFSD 291_ FLLDP 296_ YKYMT 301_ LNPST 306_ KRKNT 311_ GSPDR 316_ KPSKK 321_ SKTDN 326_ SSLSS 331_ PLNPK 336_ LWCHV 341_ HLKKS 346_ LSGSP 351_ LKVKN 356_ SKNSK 361_ SPEEH 366_ LEEMM 371_ KMMSP 376_ NKLHT 381_ NFHIP 386_ KKGPP 391_ AKKPG 396_ KHSDK 401_ PLKAK 406_ GRSKG 411_ ILNGQ 416_ KSTGN 421_ SKSPK 426_ KGLKT 431_ PKTKM 436_ KQMTL 441_ LDMAK 446_ GTQKM 451_ TRAPR 456_ NSGGT 461_ PRTSS 466_ KPHKH 471_ LPPAA 476_ LHLIA 481_ YYKEN 486_ KDRED 491_ KRSAL 496_ SCVIS 501_ KTARL 506_ LSSED 511_ RARLP 516_ EELRS 521_ LVQKR 526_ YELLE 531_ HKKRW 536_ ASMSE 541_ EQRKE 546_ YLKKK 551_ REELK 556_ KKLKE 561_ KAKER 566_ REKEM 571_ LERLE 576_ KQKRY 581_ EDQEL 586_ TGKNL 591_ PAFRL 596_ VDTPE 601_ GLPNT 606_ LFGDV 611_ AMVVE 616_ FLSCY 621_ SGLLL 626_ PDAQY 631_ PITAV 636_ SLMEA 641_ LSADK 646_ GGFLY 651_ LNRVL 656_ VILLQ 661_ TLLQD 666_ EIAED 671_ YGELG 676_ MKLSE 681_ IPLTL 686_ HSVSE 691_ LVRLC 696_ LRRSD 701_ VQEES 706_ EGSDT 711_ DDNKD 716_ SAAFE 721_ DNEVQ 726_ DEFLE 731_ KLETS 736_ EFFEL 741_ TSEEK 746_ LQILT 751_ ALCHR 756_ ILMTY 761_ SVQDH 766_ METRQ 771_ QMSAE 776_ LWKER 781_ LAVLK 786_ EENDK 791_ KRAEK 796_ QKRKE 801_ MEAKN 806_ KENGK 811_ VENGL 816_ GKTDR 821_ KKEIV 826_ KFEPQ 831_ VDTEA 836_ EDMIS 841_ AVKSR 846_ RLLAI 851_ QAKKE 856_ REIQE 861_ REMKV 866_ KLERQ 871_ AEEER 876_ IRKHK 881_ AAAEK 886_ AFQEG 891_ IAKAK 896_ LVMRR 901_ TPIGT 906_ DRNHN 911_ RYWLF 916_ SDEVP 921_ GLFIE 926_ KGWVH 931_ DSIDY 936_ RFNHH 941_ CKDHT 946_ VSGDE 951_ DYCPR 956_ SKKAN 961_ LGKNA 966_ SMNTQ 971_ HGTAT 976_ EVAVE 981_ TTTPK 986_ QGQNL 991_ WFLCD 996_ SQKEL 1001_ DELLN 1006_ CLHPQ 1011_ GIRES 1016_ QLKER 1021_ LEKRY 1026_ QDIIH 1031_ SIHLA 1036_ RKPNL 1041_ GLKSC 1046_ DGNQE 1051_ LLNFL 1056_ RSDLI 1061_ EVATR 1066_ LQKGG 1071_ LGYVE 1076_ ETSEF 1081_ EARVI 1086_ SLEKL 1091_ KDFGE 1096_ CVIAL 1101_ QASVI 1106_ KKFLQ 1111_ GFMAP 1116_ KQKRR 1121_ KLQSE 1126_ DSAKT 1131_ EEVDE 1136_ EKKMV 1141_ EEAKV 1146_ ASALE 1151_ KWKTA 1156_ IREAQ 1161_ TFSRM 1166_ HVLLG 1171_ MLDAC 1176_ IKWDM 1181_ SAENA 1186_ RCKVC 1191_ RKKGE 1196_ DDKLI 1201_ LCDEC 1206_ NKAFH 1211_ LFCLR 1216_ PALYE 1221_ VPDGE 1226_ WQCPA 1231_ CQPAT 1236_ ARRNS 1241_ RGRNY 1246_ TEESA 1251_ SEDSE 1256_ DDESD 1261_ EEEEE 1266_ EEEEE 1271_ EEEDY 1276_ EVAGL 1281_ RLRPR 1286_ KTIRG 1291_ KHSVI 1296_ PPAAR 1301_ SGRRP 1306_ GKKPH 1311_ STRRS 1316_ QPKAP 1321_ PVDDA 1326_ EVDEL 1331_ VLQTK 1336_ RSSRR 1341_ QSLEL 1346_ QKCEE 1351_ ILHKI 1356_ VKYRF 1361_ SWPFR 1366_ EPVTR 1371_ DEAED 1376_ YYDVI 1381_ THPMD 1386_ FQTVQ 1391_ NKCSC 1396_ GSYRS 1401_ VQEFL 1406_ TDMKQ 1411_ VFTNA 1416_ EVYNC 1421_ RGSHV 1426_ LSCMV 1431_ KTEQC 1436_ LVALL 1441_ HKHLP 1446_ GHPYV 1451_ RRKRK 1456_ KFPDR 1461_ LAEDE 1466_ GDSEP 1471_ EAVGQ 1476_SRGRR
1: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136)