ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1)
1_MAVTA 6_ LAART 11_ WLGVW 16_ GVRTM 21_ QARGF 26_ GSDQS 31_ ENVDR 36_ GAGSI 41_ REAGG 46_ AFGKR 51_ EQAEE 56_ ERYFR 61_ AQSRE 66_ QLAAL 71_ KKHHE 76_ EEIVH 81_ HKKEI 86_ ERLQK 91_ EIERH 96_ KQKIK 101_MLKHD
1: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme