Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372)
1_MAPSG 6_ PGSSA 11_ RRRCR 16_ RVLYW 21_ IPVVF 26_ ITLLL 31_ GWSYY 36_ AYAIQ 41_ LCIVS 46_ MENTG 51_ EQVVC 56_ LMAYH 61_ LLFAM 66_ FVWSY 71_ WKTIF 76_ TLPMN 81_ PSKEF 86_ HLSYA 91_ EKDLL 96_ EREPR 101_ GEAHQ 106_ EVLRR 111_ AAKDL 116_ PIYTR 121_ TMSGA 126_ IRYCD 131_ RCQLI 136_ KPDRC 141_ HHCSV 146_ CDKCI 151_ LKMDH 156_ HCPWV 161_ NNCVG 166_ FSNYK 171_ FFLLF 176_ LAYSL 181_ LYCLF 186_ IAATD 191_ LQYFI 196_ KFWTN 201_ GLPDT 206_ QAKFH 211_ IMFLF 216_ FAAAM 221_ FSVSL 226_ SSLFG 231_ YHCWL 236_ VSKNK 241_ STLEA 246_ FRSPV 251_ FRHGT 256_ DKNGF 261_ SLGFS 266_ KNMRQ 271_ VFGDE 276_ KKYWL 281_ LPIFS 286_ SLGDG 291_ CSFPT 296_ CLVNQ 301_ DPEQA 306_ STPAG 311_ LNSTA 316_ KNLEN 321_ HQFPA 326_ KPLRE 331_ SQSHL 336_ LTDSQ 341_ SWTES 346_ SINPG 351_ KCKAG 356_ MSNPA 361_LTMEN
1: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844)
2: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation