Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1)
1_MFQAS 6_ MRSPN 11_ MEPFK 16_ QQKVE 21_ DFYDI 26_ GEELG 31_ SGQFA 36_ IVKKC 41_ REKST 46_ GLEYA 51_ AKFIK 56_ KRQSR 61_ ASRRG 66_ VSREE 71_ IEREV 76_ SILRQ 81_ VLHHN 86_ VITLH 91_ DVYEN 96_ RTDVV 101_ LILEL 106_ VSGGE 111_ LFDFL 116_ AQKES 121_ LSEEE 126_ ATSFI 131_ KQILD 136_ GVNYL 141_ HTKKI 146_ AHFDL 151_ KPENI 156_ MLLDK 161_ NIPIP 166_ HIKLI 171_ DFGLA 176_ HEIED 181_ GVEFK 186_ NIFGT 191_ PEFVA 196_ PEIVN 201_ YEPLG 206_ LEADM 211_ WSIGV 216_ ITYIL 221_ LSGAS 226_ PFLGD 231_ TKQET 236_ LANIT 241_ AVSYD 246_ FDEEF 251_ FSQTS 256_ ELAKD 261_ FIRKL 266_ LVKET 271_ RKRLT 276_ IQEAL 281_ RHPWI 286_ TPVDN 291_ QQAMV 296_ RRESV 301_ VNLEN 306_ FRKQY 311_ VRRRW 316_ KLSFS 321_ IVSLC 326_ NHLTR 331_ SLMKK 336_ VHLRP 341_ DEDLR 346_ NCESD 351_ TEEDI 356_ ARRKA 361_LHPRR
1: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421)
2: Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death