Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form]
1_MEPFT 6_ NDRLQ 11_ LPRNM 16_ IENSM 21_ FEEEP 26_ DVVDL 31_ AKEPC 36_ LHPLE 41_ PDEVE 46_ YEPRG 51_ SRLLV 56_ RGLGE 61_ HEMEE 66_ DEEDY 71_ ESSAK 76_ LLGMS 81_ FMNRS 86_ SGLRN 91_ SATGY 96_ RQSPD 101_ GACSV 106_ PSART 111_ MVVCA 116_ FVIVV 121_ AVSVI 126_ MVIYL 131_ LPRCT 136_ FTKEG 141_ CHKKN 146_ QSIGL 151_ IQPFA 156_ TNGKL 161_ FPWAQ 166_ IRLPT 171_ AVVPL 176_ RYELS 181_ LHPNL 186_ TSMTF 191_ RGSVT 196_ ISVQA 201_ LQVTW 206_ NIILH 211_ STGHN 216_ ISRVT 221_ FMSAV 226_ SSQEK 231_ QAEIL 236_ EYAYH 241_ GQIAI 246_ VAPEA 251_ LLAGH 256_ NYTLK 261_ IEYSA 266_ NISSS 271_ YYGFY 276_ GFSYT 281_ DESNE 286_ KKYFA 291_ ATQFE 296_ PLAAR 301_ SAFPC 306_ FDEPA 311_ FKATF 316_ IIKII 321_ RDEQY 326_ TALSN 331_ MPKKS 336_ SVVLD 341_ DGLVQ 346_ DEFSE 351_ SVKMS 356_ TYLVA 361_ FIVGE 366_ MKNLS 371_ QDVNG 376_ TLVSI 381_ YAVPE 386_ KIGQV 391_ HYALE 396_ TTVKL 401_ LEFFQ 406_ NYFEI 411_ QYPLK 416_ KLDLV 421_ AIPDF 426_ EAGAM 431_ ENWGL 436_ LTFRE 441_ ETLLY 446_ DSNTS 451_ SMADR 456_ KLVTK 461_ IIAHE 466_ LAHQW 471_ FGNLV 476_ TMKWW 481_ NDLWL 486_ NEGFA 491_ TFMEY 496_ FSLEK 501_ IFKEL 506_ SSYED 511_ FLDAR 516_ FKTMK 521_ KDSLN 526_ SSHPI 531_ SSSVQ 536_ SSEQI 541_ EEMFD 546_ SLSYF 551_ KGSSL 556_ LLMLK 561_ TYLSE 566_ DVFQH 571_ AVVLY 576_ LHNHS 581_ YASIQ 586_ SDDLW 591_ DSFNE 596_ VTNQT 601_ LDVKR 606_ MMKTW 611_ TLQKG 616_ FPLVT 621_ VQKKG 626_ KELFI 631_ QQERF 636_ FLNMK 641_ PEIQP 646_ SDTSY 651_ LWHIP 656_ LSYVT 661_ EGRNY 666_ SKYQS 671_ VSLLD 676_ KKSGV 681_ INLTE 686_ EVLWV 691_ KVNIN 696_ MNGYY 701_ IVHYA 706_ DDDWE 711_ ALIHQ 716_ LKINP 721_ YVLSD 726_ KDRAN 731_ LINNI 736_ FELAG 741_ LGKVP 746_ LKRAF 751_ DLINY 756_ LGNEN 761_ HTAPI 766_ TEALF 771_ QTDLI 776_ YNLLE 781_ KLGYM 786_ DLASR 791_ LVTRV 796_ FKLLQ 801_ NQIQQ 806_ QTWTD 811_ EGTPS 816_ MRELR 821_ SALLE 826_ FACTH 831_ NLGNC 836_ STTAM 841_ KLFDD 846_ WMASN 851_ GTQSL 856_ PTDVM 861_ TTVFK 866_ VGAKT 871_ DKGWS 876_ FLLGK 881_ YISIG 886_ SEAEK 891_ NKILE 896_ ALASS 901_ EDVRK 906_ LYWLM 911_ KSSLN 916_ GDNFR 921_ TQKLS 926_ FIIRT 931_ VGRHF 936_ PGHLL 941_ AWDFV 946_ KENWN 951_ KLVQK 956_ FPLGS 961_ YTIQN 966_ IVAGS 971_ TYLFS 976_ TKTHL 981_ SEVQA 986_ FFENQ 991_ SEATF 996_ RLRCV 1001_ QEALE 1006_ VIQLN 1011_ IQWME 1016_KNLKS
1: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain