Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1)
1_MAEDW 6_ LDCPA 11_ LGPGW 16_ KRREV 21_ FRKSG 26_ ATCGR 31_ SDTYY 36_ QSPTG 41_ DRIRS 46_ KVELT 51_ RYLGP 56_ ACDLT 61_ LFDFK 66_ QGILC 71_ YPAPK 76_ AHPVA 81_ VASKK 86_ RKKPS 91_ RPAKT 96_ RKRQV 101_ GPQSG 106_ EVRKE 111_ APRDE 116_ TKADT 121_ DTAPA 126_ SFPAP 131_ GCCEN 136_ CGISF 141_ SGDGT 146_ QRQRL 151_ KTLCK 156_ DCRAQ 161_ RIAFN 166_ REQRM 171_ FKRVG 176_ CGECA 181_ ACQVT 186_ EDCGA 191_ CSTCL 196_ LQLPH 201_ DVASG 206_ LFCKC 211_ ERRRC 216_ LRIVE 221_ RSRGC 226_ GVCRG 231_ CQTQE 236_ DCGHC 241_ PICLR 246_ PPRPG 251_ LRRQW 256_ KCVQR 261_ RCLRG 266_ KHARR 271_ KGGCD 276_ SKMAA 281_ RRRPG 286_ AQPLP 291_ PPPPS 296_ QSPEP 301_ TEPHP 306_ RALAP 311_ SPPAE 316_ FIYYC 321_ VDEDE 326_ LQPYT 331_ NRRQN 336_ RKCGA 341_ CAACL 346_ RRMDC 351_ GRCDF 356_ CCDKP 361_ KFGGS 366_ NQKRQ 371_ KCRWR 376_ QCLQF 381_ AMKRL 386_ LPSVW 391_ SESED 396_ GAGSP 401_ PPYRR 406_ RKRPS 411_ SARRH 416_ HLGPT 421_ LKPTL 426_ ATRTA 431_ QPDHT 436_ QAPTK 441_ QEAGG 446_ GFVLP 451_ PPGTD 456_ LVFLR 461_ EGASS 466_ PVQVP 471_ GPVAA 476_ STEAL 481_ LQEAQ 486_ CSGLS 491_ WVVAL 496_ PQVKQ 501_ EKADT 506_ QDEWT 511_ PGTAV 516_ LTSPV 521_ LVPGC 526_ PSKAV 531_ DPGLP 536_ SVKQE 541_ PPDPE 546_ EDKEE 551_ NKDDS 556_ ASKLA 561_ PEEEA 566_ GGAGT 571_ PVITE 576_ IFSLG 581_ GTRFR 586_ DTAVW 591_ LPRSK 596_DLKKP
1: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters