Homeobox protein SIX4 (Sine oculis homeobox homolog 4)
1_MSSSS 6_ PTGQI 11_ ASAAD 16_ IKQEN 21_ GMESA 26_ SEGQE 31_ AHREV 36_ AGGAA 41_ VGLSP 46_ PAPAP 51_ FPLEP 56_ GDAAT 61_ AAARV 66_ SGEEG 71_ AVAAA 76_ AAGAA 81_ ADQVQ 86_ LHSEL 91_ LGRHH 96_ HAAAA 101_ AAQTP 106_ LAFSP 111_ DHVAC 116_ VCEAL 121_ QQGGN 126_ LDRLA 131_ RFLWS 136_ LPQSD 141_ LLRGN 146_ ESLLK 151_ ARALV 156_ AFHQG 161_ IYPEL 166_ YSILE 171_ SHSFE 176_ SANHP 181_ LLQQL 186_ WYKAR 191_ YTEAE 196_ RARGR 201_ PLGAV 206_ DKYRL 211_ RRKFP 216_ LPRTI 221_ WDGEE 226_ TVYCF 231_ KEKSR 236_ NALKE 241_ LYKQN 246_ RYPSP 251_ AEKRH 256_ LAKIT 261_ GLSLT 266_ QVSNW 271_ FKNRR 276_ QRDRN 281_ PSETQ 286_ SKSES 291_ DGNPS 296_ TEDES 301_ SKGHE 306_ DLSPH 311_ PLSSS 316_ SDGIT 321_ NLSLS 326_ SHMEP 331_ VYMQQ 336_ IGNAK 341_ ISLSS 346_ SGVLL 351_ NGSLV 356_ PASTS 361_ PVFLN 366_ GNSFI 371_ QGPSG 376_ VILNG 381_ LNVGN 386_ TQAVA 391_ LNPPK 396_ MSSNI 401_ VSNGI 406_ SMTDI 411_ LGSTS 416_ QDVKE 421_ FKVLQ 426_ SSANS 431_ ATTTS 436_ YSPSV 441_ PVSFP 446_ GLIPS 451_ TEVKR 456_ EGIQT 461_ VASQD 466_ GGSVV 471_ TFTTP 476_ VQINQ 481_ YGIVQ 486_ IPNSG 491_ ANSQF 496_ LNGSI 501_ GFSPL 506_ QLPPV 511_ SVAAS 516_ QGNIS 521_ VSSST 526_ SDGST 531_ FTSES 536_ TTVQQ 541_ GKVFL 546_ SSLAP 551_ SAVVY 556_ TVPNT 561_ GQTIG 566_ SVKQE 571_ GLERS 576_ LVFSQ 581_ LMPVN 586_ QNAQV 591_ NANLS 596_ SENIS 601_ GSGLH 606_ PLASS 611_ LVNVS 616_ PTHNF 621_ SLSPS 626_ TLLNP 631_ TELNR 636_ DIADS 641_ QPMSA 646_ PVASK 651_ STVTS 656_ VSNTN 661_ YATLQ 666_ NCSLI 671_ TGQDL 676_ LSVPM 681_ TQAAL 686_ GEIVP 691_ TAEDQ 696_ VGHPS 701_ PAVHQ 706_ DFVQE 711_ HRLVL 716_ QSVAN 721_ MKENF 726_ LSNSE 731_ SKATS 736_ SLMML 741_ DSKSK 746_ YVLDG 751_ MVDTV 756_ CEDLE 761_ TDKKE 766_ LAKLQ 771_ TVQLD 776_EDMQD
1: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis