Ventral anterior homeobox 2
1_MGDGG 6_ AERDR 11_ GPARR 16_ AESGG 21_ GGGRC 26_ GDRSG 31_ AGDLR 36_ ADGGG 41_ HSPTE 46_ VAGTS 51_ ASSPA 56_ GSRES 61_ GADSD 66_ GQPGP 71_ GEADH 76_ CRRIL 81_ VRDAK 86_ GTIRE 91_ IVLPK 96_ GLDLD 101_ RPKRT 106_ RTSFT 111_ AEQLY 116_ RLEME 121_ FQRCQ 126_ YVVGR 131_ ERTEL 136_ ARQLN 141_ LSETQ 146_ VKVWF 151_ QNRRT 156_ KQKKD 161_ QSRDL 166_ EKRAS 171_ SSASE 176_ AFATS 181_ NILRL 186_ LEQGR 191_ LLSVP 196_ RAPSL 201_ LALTP 206_ SLPGL 211_ PASHR 216_ GTSLG 221_ DPRNS 226_ SPRLN 231_ PLSSA 236_ SASPP 241_ LPPPL 246_ PAVCF 251_ SSAPL 256_ LDLPA 261_ GYELG 266_ SSAFE 271_ PYSWL 276_ ERKVG 281_SASSC
1: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina