N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase)
1_MAAIY 6_ GGVEG 11_ GGTRS 16_ EVLLV 21_ SEDGK 26_ ILAEA 31_ DGLST 36_ NHWLI 41_ GTDKC 46_ VERIN 51_ EMVNR 56_ AKRKA 61_ GVDPL 66_ VPLRS 71_ LGLSL 76_ SGGDQ 81_ EDAGR 86_ ILIEE 91_ LRDRF 96_ PYLSE 101_ SYLIT 106_ TDAAG 111_ SIATA 116_ TPDGG 121_ VVLIS 126_ GTGSN 131_ CRLIN 136_ PDGSE 141_ SGCGG 146_ WGHMM 151_ GDEGS 156_ AYWIA 161_ HQAVK 166_ IVFDS 171_ IDNLE 176_ AAPHD 181_ IGYVK 186_ QAMFH 191_ YFQVP 196_ DRLGI 201_ LTHLY 206_ RDFDK 211_ CRFAG 216_ FCRKI 221_ AEGAQ 226_ QGDPL 231_ SRYIF 236_ RKAGE 241_ MLGRH 246_ IVAVL 251_ PEIDP 256_ VLFQG 261_ KIGLP 266_ ILCVG 271_ SVWKS 276_ WELLK 281_ EGFLL 286_ ALTQG 291_ REIQA 296_ QNFFS 301_ SFTLM 306_ KLRHS 311_ SALGG 316_ ASLGA 321_ RHIGH 326_ LLPMD 331_ YSANA 336_IAFYS
1: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:22692205). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575)