C-type lectin domain family 4 member K (Langerin) (CD antigen CD207)
1_MTVEK 6_ EAPDA 11_ HFTVD 16_ KQNIS 21_ LWPRE 26_ PPPKS 31_ GPSLV 36_ PGKTP 41_ TVRAA 46_ LICLT 51_ LVLVA 56_ SVLLQ 61_ AVLYP 66_ RFMGT 71_ ISDVK 76_ TNVQL 81_ LKGRV 86_ DNIST 91_ LDSEI 96_ KKNSD 101_ GMEAA 106_ GVQIQ 111_ MVNES 116_ LGYVR 121_ SQFLK 126_ LKTSV 131_ EKANA 136_ QIQIL 141_ TRSWE 146_ EVSTL 151_ NAQIP 156_ ELKSD 161_ LEKAS 166_ ALNTK 171_ IRALQ 176_ GSLEN 181_ MSKLL 186_ KRQND 191_ ILQVV 196_ SQGWK 201_ YFKGN 206_ FYYFS 211_ LIPKT 216_ WYSAE 221_ QFCVS 226_ RNSHL 231_ TSVTS 236_ ESEQE 241_ FLYKT 246_ AGGLI 251_ YWIGL 256_ TKAGM 261_ EGDWS 266_ WVDDT 271_ PFNKV 276_ QSVRF 281_ WIPGE 286_ PNNAG 291_ NNEHC 296_ GNIKA 301_ PSLQA 306_ WNDAP 311_ CDKTF 316_ LFICK 321_RPYVP
1: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation