2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2)
1_MPDSN 6_ FAERS 11_ EEQVS 16_ GAKVI 21_ AQALK 26_ TQDVE 31_ YIFGI 36_ VGIPV 41_ TEIAI 46_ AAQQL 51_ GIKYI 56_ GMRNE 61_ QAACY 66_ AASAI 71_ GYLTS 76_ RPGVC 81_ LVVSG 86_ PGLIH 91_ ALGGM 96_ ANANM 101_ NCWPL 106_ LVIGG 111_ SSERN 116_ QETMG 121_ AFQEF 126_ PQVEA 131_ CRLYT 136_ KFSAR 141_ PSSIE 146_ AIPFV 151_ IEKAV 156_ RSSIY 161_ GRPGA 166_ CYVDI 171_ PADFV 176_ NLQVN 181_ VNSIK 186_ YMERC 191_ MSPPI 196_ SMAET 201_ SAVCT 206_ AASVI 211_ RNAKQ 216_ PLLII 221_ GKGAA 226_ YAHAE 231_ ESIKK 236_ LVEQY 241_ KLPFL 246_ PTPMG 251_ KGVVP 256_ DNHPY 261_ CVGAA 266_ RSRAL 271_ QFADV 276_ IVLFG 281_ ARLNW 286_ ILHFG 291_ LPPRY 296_ QPDVK 301_ FIQVD 306_ ICAEE 311_ LGNNV 316_ KPAVT 321_ LLGNI 326_ HAVTK 331_ QLLEE 336_ LDKTP 341_ WQYPP 346_ ESKWW 351_ KTLRE 356_ KMKSN 361_ EAASK 366_ ELASK 371_ KSLPM 376_ NYYTV 381_ FYHVQ 386_ EQLPR 391_ DCFVV 396_ SEGAN 401_ TMDIG 406_ RTVLQ 411_ NYLPR 416_ HRLDA 421_ GTFGT 426_ MGVGL 431_ GFAIA 436_ AAVVA 441_ KDRSP 446_ GQWII 451_ CVEGD 456_ SAFGF 461_ SGMEV 466_ ETICR 471_ YNLPI 476_ ILLVV 481_ NNNGI 486_ YQGFD 491_ TDTWK 496_ EMLKF 501_ QDATA 506_ VVPPM 511_ CLLPN 516_ SHYEQ 521_ VMTAF 526_ GGKGY 531_ FVQTP 536_ EELQK 541_ SLRQS 546_ LADTT 551_ KPSLI 556_ NIMIE 561_ PQATR 566_ KAQDF 571_HWLTR
1: Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:10468558, PubMed:21708296, PubMed:28289220). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:10468558, PubMed:21708296, PubMed:28289220). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity)