Cardiolipin synthase (CMP-forming) (CLS) (EC 2.7.8.41) (Protein GCD10 homolog)
1_MLALR 6_ VARGS 11_ WGALR 16_ GAAWA 21_ PGTRP 26_ SKRRA 31_ CWALL 36_ PPVPC 41_ CLGCL 46_ AERWR 51_ LRPAA 56_ LGLRL 61_ PGIGQ 66_ RNHCS 71_ GAGKA 76_ APRPA 81_ AGAGA 86_ AAEAP 91_ GGQWG 96_ PASTP 101_ SLYEN 106_ PWTIP 111_ NMLSM 116_ TRIGL 121_ APVLG 126_ YLIIE 131_ EDFNI 136_ ALGVF 141_ ALAGL 146_ TDLLD 151_ GFIAR 156_ NWANQ 161_ RSALG 166_ SALDP 171_ LADKI 176_ LISIL 181_ YVSLT 186_ YADLI 191_ PVPLT 196_ YMIIS 201_ RDVML 206_ IAAVF 211_ YVRYR 216_ TLPTP 221_ RTLAK 226_ YFNPC 231_ YATAR 236_ LKPTF 241_ ISKVN 246_ TAVQL 251_ ILVAA 256_ SLAAP 261_ VFNYA 266_ DSIYL 271_ QILWC 276_ FTAFT 281_ TAASA 286_ YSYYH 291_ YGRKT 296_VQVIK
1: Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG) (PubMed:16547353, PubMed:16678169, PubMed:16716149, PubMed:35147173). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions (PubMed:35147173)