DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8)
1_MNGEY 6_ RGRGF 11_ GRGRF 16_ QSWKR 21_ GRGGG 26_ NFSGK 31_ WRERE 36_ HRPDL 41_ SKTTG 46_ KRTSE 51_ QTPQF 56_ LLSTK 61_ TPQSM 66_ QSTLD 71_ RFIPY 76_ KGWKL 81_ YFSEV 86_ YSDSS 91_ PLIEK 96_ IQAFE 101_ KFFTR 106_ HIDLY 111_ DKDEI 116_ ERKGS 121_ ILVDF 126_ KELTE 131_ GGEVT 136_ NLIPD 141_ IATEL 146_ RDAPE 151_ KTLAC 156_ MGLAI 161_ HQVLT 166_ KDLER 171_ HAAEL 176_ QAQEG 181_ LSNDG 186_ ETMVN 191_ VPHIH 196_ ARVYN 201_ YEPLT 206_ QLKNV 211_ RANYY 216_ GKYIA 221_ LRGTV 226_ VRVSN 231_ IKPLC 236_ TKMAF 241_ LCAAC 246_ GEIQS 251_ FPLPD 256_ GKYSL 261_ PTKCP 266_ VPVCR 271_ GRSFT 276_ ALRSS 281_ PLTVT 286_ MDWQS 291_ IKIQE 296_ LMSDD 301_ QREAG 306_ RIPRT 311_ IECEL 316_ VHDLV 321_ DSCVP 326_ GDTVT 331_ ITGIV 336_ KVSNA 341_ EEGSR 346_ NKNDK 351_ CMFLL 356_ YIEAN 361_ SISNS 366_ KGQKT 371_ KSSED 376_ GCKHG 381_ MLMEF 386_ SLKDL 391_ YAIQE 396_ IQAEE 401_ NLFKL 406_ IVNSL 411_ CPVIF 416_ GHELV 421_ KAGLA 426_ LALFG 431_ GSQKY 436_ ADDKN 441_ RIPIR 446_ GDPHI 451_ LVVGD 456_ PGLGK 461_ SQMLQ 466_ AACNV 471_ APRGV 476_ YVCGN 481_ TTTTS 486_ GLTVT 491_ LSKDS 496_ SSGDF 501_ ALEAG 506_ ALVLG 511_ DQGIC 516_ GIDEF 521_ DKMGN 526_ QHQAL 531_ LEAME 536_ QQSIS 541_ LAKAG 546_ VVCSL 551_ PARTS 556_ IIAAA 561_ NPVGG 566_ HYNKA 571_ KTVSE 576_ NLKMG 581_ SALLS 586_ RFDLV 591_ FILLD 596_ TPNEH 601_ HDHLL 606_ SEHVI 611_ AIRAG 616_ KQRTI 621_ SSATV 626_ ARMNS 631_ QDSNT 636_ SVLEV 641_ VSEKP 646_ LSERL 651_ KVVPG 656_ ETIDP 661_ IPHQL 666_ LRKYI 671_ GYARQ 676_ YVYPR 681_ LSTEA 686_ ARVLQ 691_ DFYLE 696_ LRKQS 701_ QRLNS 706_ SPITT 711_ RQLES 716_ LIRLT 721_ EARAR 726_ LELRE 731_ EATKE 736_ DAEDI 741_ VEIMK 746_ YSMLG 751_ TYSDE 756_ FGNLD 761_ FERSQ 766_ HGSGM 771_ SNRST 776_ AKRFI 781_ SALNN 786_ VAERT 791_ YNNIF 796_ QFHQL 801_ RQIAK 806_ ELNIQ 811_ VADFE 816_ NFIGS 821_ LNDQG 826_ YLLKK 831_GPKVY
1: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093)