ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)
1_MSIAG 6_ VAAQE 11_ IRVPL 16_ KTGFL 21_ HNGRA 26_ MGNMR 31_ KTYWS 36_ SRSEF 41_ KNNFL 46_ NIDPI 51_ TMAYS 56_ LNSSA 61_ QERLI 66_ PLGHA 71_ SKSAP 76_ MNGHC 81_ FAENG 86_ PSQKS 91_ SLPPL 96_ LIPPS 101_ ENLGP 106_ HEEDQ 111_ VVCGF 116_ KKLTV 121_ NGVCA 126_ STPPL 131_ TPIKN 136_ SPSLF 141_ PCAPL 146_ CERGS 151_ RPLPP 156_ LPISE 161_ ALSLD 166_ DTDCE 171_ VEFLT 176_ SSDTD 181_ FLLED 186_ STLSD 191_ FKYDV 196_ PGRRS 201_ FRGCG 206_ QINYA 211_ YFDTP 216_ AVSAA 221_ DLSYV 226_ SDQNG 231_ GVPDP 236_ NPPPP 241_ QTHRR 246_ LRRSH 251_ SGPAG 256_ SFNKP 261_ AIRIS 266_ NCCIH 271_ RASPN 276_ SDEDK 281_ PEVPP 286_ RVPIP 291_ PRPVK 296_ PDYRR 301_ WSAEV 306_ TSSTY 311_ SDEDR 316_ PPKVP 321_ PREPL 326_ SPSNS 331_ RTPSP 336_ KSLPS 341_ YLNGV 346_ MPPTQ 351_ SFAPD 356_ PKYVS 361_ SKALQ 366_ RQNSE 371_ GSASK 376_ VPCIL 381_ PIIEN 386_ GKKVS 391_ STHYY 396_ LLPER 401_ PPYLD 406_ KYEKF 411_ FREAE 416_ ETNGG 421_ AQIQP 426_ LPADC 431_ GISSA 436_ TEKPD 441_ SKTKM 446_ DLGGH 451_ VKRKH 456_LSYVV
1: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity)