F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7)
1_MGANN 6_ GKQYG 11_ SEGKG 16_ SSSIS 21_ SDVSS 26_ STDHT 31_ PTKAQ 36_ KNVAT 41_ SEDSD 46_ LSMRT 51_ LSTPS 56_ PALIC 61_ PPNLP 66_ GFQNG 71_ RGSST 76_ SSSSI 81_ TGETV 86_ AMVHS 91_ PPPTR 96_ LTHPL 101_ IRLAS 106_ RPQKE 111_ QASID 116_ RLPDH 121_ SMVQI 126_ FSFLP 131_ TNQLC 136_ RCARV 141_ CRRWY 146_ NLAWD 151_ PRLWR 156_ TIRLT 161_ GETIN 166_ VDRAL 171_ KVLTR 176_ RLCQD 181_ TPNVC 186_ LMLET 191_ VTVSG 196_ CRRLT 201_ DRGLY 206_ TIAQC 211_ CPELR 216_ RLEVS 221_ GCYNI 226_ SNEAV 231_ FDVVS 236_ LCPNL 241_ EHLDV 246_ SGCSK 251_ VTCIS 256_ LTREA 261_ SIKLS 266_ PLHGK 271_ QISIR 276_ YLDMT 281_ DCFVL 286_ EDEGL 291_ HTIAA 296_ HCTQL 301_ THLYL 306_ RRCVR 311_ LTDEG 316_ LRYLV 321_ IYCAS 326_ IKELS 331_ VSDCR 336_ FVSDF 341_ GLREI 346_ AKLES 351_ RLRYL 356_ SIAHC 361_ GRVTD 366_ VGIRY 371_ VAKYC 376_ SKLRY 381_ LNARG 386_ CEGIT 391_ DHGVE 396_ YLAKN 401_ CTKLK 406_ SLDIG 411_ KCPLV 416_ SDTGL 421_ ECLAL 426_ NCFNL 431_ KRLSL 436_ KSCES 441_ ITGQG 446_ LQIVA 451_ ANCFD 456_ LQTLN 461_ VQDCE 466_ VSVEA 471_ LRFVK 476_ RHCKR 481_ CVIEH 486_TNPAF
1: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:25778398). During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398, PubMed:28218735)