Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)
1_MPQLS 6_ GGGGG 11_ GGGDP 16_ ELCAT 21_ DEMIP 26_ FKDEG 31_ DPQKE 36_ KIFAE 41_ ISHPE 46_ EEGDL 51_ ADIKS 56_ SLVNE 61_ SEIIP 66_ ASNGH 71_ EVARQ 76_ AQTSQ 81_ EPYHD 86_ KAREH 91_ PDDGK 96_ HPDGG 101_ LYNKG 106_ PSYSS 111_ YSGYI 116_ MMPNM 121_ NNDPY 126_ MSNGS 131_ LSPPI 136_ PRTSN 141_ KVPVV 146_ QPSHA 151_ VHPLT 156_ PLITY 161_ SDEHF 166_ SPGSH 171_ PSHIP 176_ SDVNS 181_ KQGMS 186_ RHPPA 191_ PDIPT 196_ FYPLS 201_ PGGVG 206_ QITPP 211_ LGWQG 216_ QPVYP 221_ ITGGF 226_ RQPYP 231_ SSLSV 236_ DTSMS 241_ RFSHH 246_ MIPGP 251_ PGPHT 256_ TGIPH 261_ PAIVT 266_ PQVKQ 271_ EHPHT 276_ DSDLM 281_ HVKPQ 286_ HEQRK 291_ EQEPK 296_ RPHIK 301_ KPLNA 306_ FMLYM 311_ KEMRA 316_ NVVAE 321_ CTLKE 326_ SAAIN 331_ QILGR 336_ RWHAL 341_ SREEQ 346_ AKYYE 351_ LARKE 356_ RQLHM 361_ QLYPG 366_ WSARD 371_ NYGKK 376_ KKRKR 381_ EKLQE 386_ SASGT 391_GPRMT
1: Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity)
2: Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells
3: Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling
4: Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells