Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7)
1_MAANL 6_ SRNGP 11_ ALQEA 16_ YVRVV 21_ TEKSP 26_ TDWAL 31_ FTYEG 36_ NSNDI 41_ RVAGT 46_ GEGGL 51_ EEMVE 56_ ELNSG 61_ KVMYA 66_ FCRVK 71_ DPNSG 76_ LPKFV 81_ LINWT 86_ GEGVN 91_ DVRKG 96_ ACASH 101_ VSTMA 106_ SFLKG 111_ AHVTI 116_ NARAE 121_ EDVEP 126_ ECIME 131_ KVAKA 136_ SGANY 141_ SFHKE 146_ SGRFQ 151_ DVGPQ 156_ APVGS 161_ VYQKT 166_ NAVSE 171_ IKRVG 176_ KDSFW 181_ AKAEK 186_ EEENR 191_ RLEEK 196_ RRAEE 201_ AQRQL 206_ EQERR 211_ ERELR 216_ EAARR 221_ EQRYQ 226_ EQGGE 231_ ASPQR 236_ TWEQQ 241_ QEVVS 246_ RNRNE 251_ QESAV 256_ HPREI 261_ FKQKE 266_ RAMST 271_ TSISS 276_ PQPGK 281_ LRSPF 286_ LQKQL 291_ TQPET 296_ HFGRE 301_ PAAAI 306_ SRPRA 311_ DLPAE 316_ EPAPS 321_ TPPCL 326_ VQAEE 331_ EAVYE 336_ EPPEQ 341_ ETFYE 346_ QPPLV 351_ QQQGA 356_ GSEHI 361_ DHHIQ 366_ GQGLS 371_ GQGLC 376_ ARALY 381_ DYQAA 386_ DDTEI 391_ SFDPE 396_ NLITG 401_ IEVID 406_ EGWWR 411_ GYGPD 416_ GHFGM 421_FPANY
1: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes