Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)
1_MGESP 6_ ASVVL 11_ NASGG 16_ LFSLK 21_ METLE 26_ SELTC 31_ PICLE 36_ LFEDP 41_ LLLPC 46_ AHSLC 51_ FSCAH 56_ RILVS 61_ SCSSG 66_ ESIEP 71_ ITAFQ 76_ CPTCR 81_ YVISL 86_ NHRGL 91_ DGLKR 96_ NVTLQ 101_ NIIDR 106_ FQKAS 111_ VSGPN 116_ SPSES 121_ RRERT 126_ YRPTT 131_ AMSSE 136_ RIACQ 141_ FCEQD 146_ PPRDA 151_ VKTCI 156_ TCEVS 161_ YCDRC 166_ LRATH 171_ PNKKP 176_ FTSHR 181_ LVEPV 186_ PDTHL 191_ RGITC 196_ LDHEN 201_ EKVNM 206_ YCVSD 211_ DQLIC 216_ ALCKL 221_ VGRHR 226_ DHQVA 231_ SLNDR 236_ FEKLK 241_ QTLEM 246_ NLTNL 251_ VKRNS 256_ ELENQ 261_ MAKLI 266_ QICQQ 271_ VEVNT 276_ AMHEA 281_ KLMEE 286_ CDELV 291_ EIIQQ 296_ RKQMI 301_ AVKIK 306_ ETKVM 311_ KLRKL 316_ AQQVA 321_ NCRQC 326_ LERST 331_ VLINQ 336_ AEHIL 341_ KENDQ 346_ ARFLQ 351_ SAKNI 356_ AERVA 361_ MATAS 366_ SQVLI 371_ PDINF 376_ NDAFE 381_ NFALD 386_ FSREK 391_ KLLEG 396_ LDYLT 401_ APNPP 406_ SIREE 411_ LCTAS 416_ HDTIT 421_ VHWIS 426_ DDEFS 431_ ISSYE 436_ LQYTI 441_ FTGQA 446_ NFISK 451_ SWCSW 456_ GLWPE 461_ IRKCK 466_ EAVSC 471_ SRLAG 476_ APRGL 481_ YNSVD 486_ SWMIV 491_ PNIKQ 496_ NHYTV 501_ HGLQS 506_ GTRYI 511_ FIVKA 516_ INQAG 521_ SRNSE 526_ PTRLK 531_ TNSQP 536_ FKLDP 541_ KMTHK 546_ KLKIS 551_ NDGLQ 556_ MEKDE 561_ SSLKK 566_ SHTPE 571_ RFSGT 576_ GCYGA 581_ AGNIF 586_ IDSGC 591_ HYWEV 596_ VMGSS 601_ TWYAI 606_ GIAYK 611_ SAPKN 616_ EWIGK 621_ NASSW 626_ VFSRC 631_ NSNFV 636_ VRHNN 641_ KEMLV 646_ DVPPH 651_ LKRLG 656_ VLLDY 661_ DNNML 666_ SFYDP 671_ ANSLH 676_ LHTFD 681_ VTFIL 686_ PVCPT 691_ FTIWN 696_ KSLMI 701_ LSGLP 706_ APDFI 711_ DYPER 716_ QECNC 721_ RPQES 726_PYVSG
1: E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29 (PubMed:35266954)