Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog)
1_MEESE 6_ PERKR 11_ ARTDE 16_ VPAGG 21_ SRSEA 26_ EDEDD 31_ EDYVP 36_ YVPLR 41_ QRRQL 46_ LLQKL 51_ LQRRR 56_ KGAAE 61_ EEQQD 66_ SGSEP 71_ RGDED 76_ DIPLG 81_ PQSNV 86_ SLLDQ 91_ HQHLK 96_ EKAEA 101_ RKESA 106_ KEKQL 111_ KEEEK 116_ ILESV 121_ AEGRA 126_ LMSVK 131_ EMAKG 136_ ITYDD 141_ PIKTS 146_ WTPPR 151_ YVLSM 156_ SEERH 161_ ERVRK 166_ KYHIL 171_ VEGDG 176_ IPPPI 181_ KSFKE 186_ MKFPA 191_ AILRG 196_ LKKKG 201_ IHHPT 206_ PIQIQ 211_ GIPTI 216_ LSGRD 221_ MIGIA 226_ FTGSG 231_ KTLVF 236_ TLPVI 241_ MFCLE 246_ QEKRL 251_ PFSKR 256_ EGPYG 261_ LIICP 266_ SRELA 271_ RQTHG 276_ ILEYY 281_ CRLLQ 286_ EDSSP 291_ LLRCA 296_ LCIGG 301_ MSVKE 306_ QMETI 311_ RHGVH 316_ MMVAT 321_ PGRLM 326_ DLLQK 331_ KMVSL 336_ DICRY 341_ LALDE 346_ ADRMI 351_ DMGFE 356_ GDIRT 361_ IFSYF 366_ KGQRQ 371_ TLLFS 376_ ATMPK 381_ KIQNF 386_ AKSAL 391_ VKPVT 396_ INVGR 401_ AGAAS 406_ LDVIQ 411_ EVEYV 416_ KEEAK 421_ MVYLL 426_ ECLQK 431_ TPPPV 436_ LIFAE 441_ KKADV 446_ DAIHE 451_ YLLLK 456_ GVEAV 461_ AIHGG 466_ KDQEE 471_ RTKAI 476_ EAFRE 481_ GKKDV 486_ LVATD 491_ VASKG 496_ LDFPA 501_ IQHVI 506_ NYDMP 511_ EEIEN 516_ YVHRI 521_ GRTGR 526_ SGNTG 531_ IATTF 536_ INKAC 541_ DESVL 546_ MDLKA 551_ LLLEA 556_ KQKVP 561_ PVLQV 566_ LHCGD 571_ ESMLD 576_ IGGER 581_ GCAFC 586_ GGLGH 591_ RITDC 596_ PKLEA 601_ MQTKQ 606_ VSNIG 611_ RKDYL 616_AHSSM
1: Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:34473945). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses (PubMed:23222971). Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1 (PubMed:25704810). Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity (PubMed:35613581). In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:35613581). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing (PubMed:33650667). Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability (PubMed:36229594). Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis (PubMed:36229594, PubMed:36780110)