DNA (cytosine-5)-methyltransferase 3-like
1_MAAIP 6_ ALDPE 11_ AEPSM 16_ DVILV 21_ GSSEL 26_ SSSVS 31_ PGTGR 36_ DLIAY 41_ EVKAN 46_ QRNIE 51_ DICIC 56_ CGSLQ 61_ VHTQH 66_ PLFEG 71_ GICAP 76_ CKDKF 81_ LDALF 86_ LYDDD 91_ GYQSY 96_ CSICC 101_ SGETL 106_ LICGN 111_ PDCTR 116_ CYCFE 121_ CVDSL 126_ VGPGT 131_ SGKVH 136_ AMSNW 141_ VCYLC 146_ LPSSR 151_ SGLLQ 156_ RRRKW 161_ RSQLK 166_ AFYDR 171_ ESENP 176_ LEMFE 181_ TVPVW 186_ RRQPV 191_ RVLSL 196_ FEDIK 201_ KELTS 206_ LGFLE 211_ SGSDP 216_ GQLKH 221_ VVDVT 226_ DTVRK 231_ DVEEW 236_ GPFDL 241_ VYGAT 246_ PPLGH 251_ TCDRP 256_ PSWYL 261_ FQFHR 266_ LLQYA 271_ RPKPG 276_ SPRPF 281_ FWMFV 286_ DNLVL 291_ NKEDL 296_ DVASR 301_ FLEME 306_ PVTIP 311_ DVHGG 316_ SLQNA 321_ VRVWS 326_ NIPAI 331_ RSRHW 336_ ALVSE 341_ EELSL 346_ LAQNK 351_ QSSKL 356_ AAKWP 361_ TKLVK 366_ NCFLP 371_ LREYF 376_ KYFST 381_ELTSS
1: Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327). Plays a key role in embryonic stem cells and germ cells (By similarity). In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity). Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (By similarity). While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity)