SERTA domain-containing protein 3 (Replication protein-binding trans-activator) (RPA-binding trans-activator)
1_MVGGL 6_ KRKHS 11_ DLEEE 16_ EERWE 21_ WSPAG 26_ LQSYQ 31_ QALLR 36_ ISLDK 41_ VQRSL 46_ GPRAP 51_ SLRRH 56_ VLIHN 61_ TLQQL 66_ QAALR 71_ LAPAP 76_ ALPPE 81_ PLFLG 86_ EEDFS 91_ LSATI 96_ GSILR 101_ ELDTS 106_ MDGTE 111_ PPQNP 116_ VTPLG 121_ LQNEV 126_ PPQPD 131_ PVFLE 136_ ALSSR 141_ YLGDS 146_ GLDDF 151_ FLDID 156_ TSAVE 161_ KEPAR 166_ APPEP 171_ PHNLF 176_ CAPGS 181_ WEWNE 186_ LDHIM 191_EIILG
1: Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms (PubMed:33147462, PubMed:36594413). Plays a role in the late phase response of TLR-induced immune effector expression (By similarity). During influenza infection, interacts with PB2, PB1, and PA to disrupt the formation of the viral RdRp complex (PubMed:33147462). Inhibits zika virus by interacting with the capsid protein in the nucleolus and reducing its abundance through proteasomal degradation (PubMed:36594413). Strong transcriptional coactivator (PubMed:10982866)