Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)
1_MAAST 6_ SMVPV 11_ AVTAA 16_ VAPVL 21_ SINSD 26_ FSDLR 31_ EIKKQ 36_ LLLIA 41_ GLTRE 46_ RGLLH 51_ SSKWS 56_ AELAF 61_ SLPAL 66_ PLAEL 71_ QPPPP 76_ ITEED 81_ AQDMD 86_ AYTLA 91_ KAYFD 96_ VKEYD 101_ RAAHF 106_ LHGCN 111_ SKKAY 116_ FLYMY 121_ SRYLS 126_ GEKKK 131_ DDETV 136_ DSLGP 141_ LEKGQ 146_ VKNEA 151_ LRELR 156_ VELSK 161_ KHQAR 166_ ELDGF 171_ GLYLY 176_ GVVLR 181_ KLDLV 186_ KEAID 191_ VFVEA 196_ THVLP 201_ LHWGA 206_ WLELC 211_ NLITD 216_ KEMLK 221_ FLSLP 226_ DTWMK 231_ EFFLA 236_ HIYTE 241_ LQLIE 246_ EALQK 251_ YQNLI 256_ DVGFS 261_ KSSYI 266_ VSQIA 271_ VAYHN 276_ IRDID 281_ KALSI 286_ FNELR 291_ KQDPY 296_ RIENM 301_ DTFSN 306_ LLYVR 311_ SMKSE 316_ LSYLA 321_ HNLCE 326_ IDKYR 331_ VETCC 336_ VIGNY 341_ YSLRS 346_ QHEKA 351_ ALYFQ 356_ RALKL 361_ NPRYL 366_ GAWTL 371_ MGHEY 376_ MEMKN 381_ TSAAI 386_ QAYRH 391_ AIEVN 396_ KRDYR 401_ AWYGL 406_ GQTYE 411_ ILKMP 416_ FYCLY 421_ YYRRA 426_ HQLRP 431_ NDSRM 436_ LVALG 441_ ECYEK 446_ LNQLV 451_ EAKKC 456_ YWRAY 461_ AVGDV 466_ EKMAL 471_ VKLAK 476_ LHEQL 481_ TESEQ 486_ AAQCY 491_ IKYIQ 496_ DIYSC 501_ GEIVE 506_ HLEES 511_ TAFRY 516_ LAQYY 521_ FKCKL 526_ WDEAS 531_ TCAQK 536_ CCAFN 541_ DTREE 546_ GKALL 551_ RQILQ 556_ LRNQG 561_ ETPTT 566_ EVPAP 571_ FFLPA 576_ SLSAN 581_ NTPTR 586_ RVSPL 591_NLSSV
1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132)