Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7)
1_MNVID 6_ HVRDM 11_ AAAGL 16_ HSNVR 21_ LLSSL 26_ LLTMS 31_ NNNPE 36_ LFSPP 41_ QKYQL 46_ LVYHA 51_ DSLFH 56_ DKEYR 61_ NAVSK 66_ YTMAL 71_ QQKKA 76_ LSKTS 81_ KVRPS 86_ TGNSA 91_ STPQS 96_ QCLPS 101_ EIEVK 106_ YKMAE 111_ CYTML 116_ KQDKD 121_ AIAIL 126_ DGIPS 131_ RQRTP 136_ KINMM 141_ LANLY 146_ KKAGQ 151_ ERPSV 156_ TSYKE 161_ VLRQC 166_ PLALD 171_ AILGL 176_ LSLSV 181_ KGAEV 186_ ASMTM 191_ NVIQT 196_ VPNLD 201_ WLSVW 206_ IKAYA 211_ FVHTG 216_ DNSRA 221_ ISTIC 226_ SLEKK 231_ SLLRD 236_ NVDLL 241_ GSLAD 246_ LYFRA 251_ GDNKN 256_ SVLKF 261_ EQAQM 266_ LDPYL 271_ IKGMD 276_ VYGYL 281_ LAREG 286_ RLEDV 291_ ENLGC 296_ RLFNI 301_ SDQHA 306_ EPWVV 311_ SGCHS 316_ FYSKR 321_ YSRAL 326_ YLGAK 331_ AIQLN 336_ SNSVQ 341_ ALLLK 346_ GAALR 351_ NMGRV 356_ QEAII 361_ HFREA 366_ IRLAP 371_ CRLDC 376_ YEGLI 381_ ECYLA 386_ SNSIR 391_ EAMVM 396_ ANNVY 401_ KTLGA 406_ NAQTL 411_ TLLAT 416_ VCLED 421_ PVTQE 426_ KAKTL 431_ LDKAL 436_ TQRPD 441_ YIKAV 446_ VKKAE 451_ LLSRE 456_ QKYED 461_ GIALL 466_ RNALA 471_ NQSDC 476_ VLHRI 481_ LGDFL 486_ VAVNE 491_ YQEAM 496_ DQYSI 501_ ALSLD 506_ PNDQK 511_ SLEGM 516_ QKMEK 521_ EESPT 526_ DATQE 531_ EDVDD 536_ MEGSG 541_ EEGDL 546_ EGSDS 551_ EAAQW 556_ADQEQ
1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC7 is not required for the assembly of the APC/C complex, but has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates (PubMed:34942119). Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis (PubMed:34942119)