Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4)
1_MLRFP 6_ TCFPS 11_ FRVVG 16_ EKQLP 21_ QEIIF 26_ LVWSP 31_ KRDLI 36_ ALANT 41_ AGEVL 46_ LHRLA 51_ SFHRV 56_ WSFPP 61_ NENTG 66_ KEVTC 71_ LAWRP 76_ DGKLL 81_ AFALA 86_ DTKKI 91_ VLCDV 96_ EKPES 101_ LHSFS 106_ VEAPV 111_ SCMHW 116_ MEVTV 121_ ESSVL 126_ TSFYN 131_ AEDES 136_ NLLLP 141_ KLPTL 146_ PKNYS 151_ NTSKI 156_ FSEEN 161_ SDEII 166_ KLLGD 171_ VRLNI 176_ LVLGG 181_ SSGFI 186_ ELYAY 191_ GMFKI 196_ ARVTG 201_ IAGTC 206_ LALCL 211_ SSDLK 216_ SLSVV 221_ TEVST 226_ NGASE 231_ VSYFQ 236_ LETNL 241_ LYSFL 246_ PEVTR 251_ MARKF 256_ THISA 261_ LLQYI 266_ NLSLT 271_ CMCEA 276_ WEEIL 281_ MQMDS 286_ RLTKF 291_ VQEKN 296_ TTTSV 301_ QDEFM 306_ HLLLW 311_ GKASA 316_ ELQTL 321_ LMNQL 326_ TVKGL 331_ KKLGQ 336_ SIESS 341_ YSSIQ 346_ KLVIS 351_ HLQSG 356_ SESLL 361_ YHLSE 366_ LKGMA 371_ SWKQK 376_ YEPLG 381_ LDAAG 386_ IEEAI 391_ TAVGS 396_ FILKA 401_ NELLQ 406_ VIDSS 411_ MKNFK 416_ AFFRW 421_ LYVAM 426_ LRMTE 431_ DHVLP 436_ ELNKM 441_ TQKDI 446_ TFVAE 451_ FLTEH 456_ FNEAP 461_ DLYNR 466_ KGKYF 471_ NVERV 476_ GQYLK 481_ DEDDD 486_ LVSPP 491_ NTEGN 496_ QWYDF 501_ LQNSS 506_ HLKES 511_ PLLFP 516_ YYPRK 521_ SLHFV 526_ KRRME 531_ NIIDQ 536_ CLQKP 541_ ADVIG 546_ KSMNQ 551_ AICIP 556_ LYRDT 561_ RSEDS 566_ TRRLF 571_ KFPFL 576_ WNNKT 581_ SNLHY 586_ LLFTI 591_ LEDSL 596_ YKMCI 601_ LRRHT 606_ DISQS 611_ VSNGL 616_ IAIKF 621_ GSFTY 626_ ATTEK 631_ VRRSI 636_ YSCLD 641_ AQFYD 646_ DETVT 651_ VVLKD 656_ TVGRE 661_ GRDRL 666_ LVQLP 671_ LSLVY 676_ NSEDS 681_ AEYQF 686_ TGTYS 691_ TRLDE 696_ QCSAI 701_ PTRTM 706_ HFEKH 711_ WRLLE 716_ SMKAQ 721_ YVAGN 726_ GFRKV 731_ SCVLS 736_ SNLRH 741_ VRVFE 746_ MDIDD 751_ EWELD 756_ ESSDE 761_ EEEAS 766_ NKPVK 771_ IKEEV 776_ LSESE 781_ AENQQ 786_ AGAAA 791_ LAPEI 796_ VIKVE 801_KLDPE
1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132)