Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)
1_MAAAV 6_ VVAEG 11_ DSDSR 16_ PGQEL 21_ LVAWN 26_ TVSTG 31_ LVPPA 36_ ALGLV 41_ SSRTS 46_ GAVPP 51_ KEEEL 56_ RAAVE 61_ VLRGH 66_ GLHSV 71_ LEEWF 76_ VEVLQ 81_ NDLQA 86_ NISPE 91_ FWNAI 96_ SQCEN 101_ SADEP 106_ QCLLL 111_ LLDAF 116_ GLLES 121_ RLDPY 126_ LRSLE 131_ LLEKW 136_ TRLGL 141_ LMGTG 146_ AQGLR 151_ EEVHT 156_ MLRGV 161_ LFFST 166_ PRTFQ 171_ EMIQR 176_ LYGCF 181_ LRVYM 186_ QSKRK 191_ GEGGT 196_ DPELE 201_ GELDS 206_ RYARR 211_ RYYRL 216_ LQSPL 221_ CAGCS 226_ SDKQQ 231_ CWCRQ 236_ ALEQF 241_ HQLSQ 246_ VLHRL 251_ SLLER 256_ VSAEA 261_ VTTTL 266_ HQVTR 271_ ERMED 276_ RCRGE 281_ YERSF 286_ LREFH 291_ KWIER 296_ VVGWL 301_ GKVFL 306_ QDGPA 311_ RPASP 316_ EAGNT 321_ LRRWR 326_ CHVQR 331_ FFYRI 336_ YASLR 341_ IEELF 346_ SIVRD 351_ FPDSR 356_ PAIED 361_ LKYCL 366_ ERTDQ 371_ RQQLL 376_ VSLKA 381_ ALETR 386_ LLHPG 391_ VNTCD 396_ IITLY 401_ ISAIK 406_ ALRVL 411_ DPSMV 416_ ILEVA 421_ CEPIR 426_ RYLRT 431_ REDTV 436_ RQIVA 441_ GLTGD 446_ SDGTG 451_ DLAVE 456_ LSKTD 461_ PASLE 466_ TGQDS 471_ EDDSG 476_ EPEDW 481_ VPDPV 486_ DADPG 491_ KSSSK 496_ RRSSD 501_ IISLL 506_ VSIYG 511_ SKDLF 516_ INEYR 521_ SLLAD 526_ RLLHQ 531_ FSFSP 536_ EREIR 541_ NVELL 546_ KLRFG 551_ EAPMH 556_ FCEVM 561_ LKDMA 566_ DSRRI 571_ NANIR 576_ EEDEK 581_ RPAEE 586_ QPPFG 591_ VYAVI 596_ LSSEF 601_ WPPFK 606_ DEKLE 611_ VPEDI 616_ RAALE 621_ AYCKK 626_ YEQLK 631_ AMRTL 636_ SWKHT 641_ LGLVT 646_ MDVEL 651_ ADRTL 656_ SVAVT 661_ PVQAV 666_ ILLYF 671_ QDQAS 676_ WTLEE 681_ LSKAV 686_ KMPVA 691_ LLRRR 696_ MSVWL 701_ QQGVL 706_ REEPP 711_ GTFSV 716_ IEEER 721_ PQDRD 726_ NMVLI 731_ DSDDE 736_ SDSGM 741_ ASQAD 746_ QKEEE 751_ LLLFW 756_ TYIQA 761_ MLTNL 766_ ESLSL 771_ DRIYN 776_ MLRMF 781_ VVTGP 786_ ALAEI 791_ DLQEL 796_ QGYLQ 801_ KKVRD 806_ QQLVY 811_ SAGVY 816_RLPKN
1: Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11739784, PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:11739784, PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation (By similarity)