ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)
1_MEPAM 6_ EPETL 11_ EARIN 16_ RATNP 21_ LNKEL 26_ DWASI 31_ NGFCE 36_ QLNED 41_ FEGPP 46_ LATRL 51_ LAHKI 56_ QSPQE 61_ WEAIQ 66_ ALTVL 71_ ETCMK 76_ SCGKR 81_ FHDEV 86_ GKFRF 91_ LNELI 96_ KVVSP 101_ KYLGS 106_ RTSEK 111_ VKNKI 116_ LELLY 121_ SWTVG 126_ LPEEV 131_ KIAEA 136_ YQMLK 141_ KQGIV 146_ KSDPK 151_ LPDDT 156_ TFPLP 161_ PPRPK 166_ NVIFE 171_ DEEKS 176_ KMLAR 181_ LLKSS 186_ HPEDL 191_ RAANK 196_ LIKEM 201_ VQEDQ 206_ KRMEK 211_ ISKRV 216_ NAIEE 221_ VNNNV 226_ KLLTE 231_ MVMSH 236_ SQGGA 241_ AAGSS 246_ EDLMK 251_ ELYQR 256_ CERMR 261_ PTLFR 266_ LASDT 271_ EDNDE 276_ ALAEI 281_ LQAND 286_ NLTQV 291_ INLYK 296_ QLVRG 301_ EEVNG 306_ DATAG 311_ SIPGS 316_ TSALL 321_ DLSGL 326_ DLPPA 331_ GTTYP 336_ AMPTR 341_ PGEQA 346_ SPEQP 351_ SASVS 356_ LLDDE 361_ LMSLG 366_ LSDPT 371_ PPSGP 376_ SLDGT 381_ GWNSF 386_ QSSDA 391_ TEPPA 396_ PALAQ 401_ APSME 406_ SRPPA 411_ QTSLP 416_ ASSGL 421_ DDLDL 426_ LGKTL 431_ LQQSL 436_ PPESQ 441_ QVRWE 446_ KQQPT 451_ PRLTL 456_ RDLQN 461_ KSSSC 466_ SSPSS 471_ SATSL 476_ LHTVS 481_ PEPPR 486_ PPQQP 491_ VPTEL 496_ SLASI 501_ TVPLE 506_ SIKPS 511_ NILPV 516_ TVYDQ 521_ HGFRI 526_ LFHFA 531_ RDPLP 536_ GRSDV 541_ LVVVV 546_ SMLST 551_ APQPI 556_ RNIVF 561_ QSAVP 566_ KVMKV 571_ KLQPP 576_ SGTEL 581_ PAFNP 586_ IVHPS 591_ AITQV 596_ LLLAN 601_ PQKEK 606_ VRLRY 611_ KLTFT 616_ MGDQT 621_ YNEMG 626_ DVDQF 631_PPPET
1: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712, PubMed:15886016)