Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)
1_MLARA 6_ ARGTG 11_ ALLLR 16_ GSLLA 21_ SGRAP 26_ RRASS 31_ GLPRN 36_ TVVLF 41_ VPQQE 46_ AWVVE 51_ RMGRF 56_ HRILE 61_ PGLNI 66_ LIPVL 71_ DRIRY 76_ VQSLK 81_ EIVIN 86_ VPEQS 91_ AVTLD 96_ NVTLQ 101_ IDGVL 106_ YLRIM 111_ DPYKA 116_ SYGVE 121_ DPEYA 126_ VTQLA 131_ QTTMR 136_ SELGK 141_ LSLDK 146_ VFRER 151_ ESLNA 156_ SIVDA 161_ INQAA 166_ DCWGI 171_ RCLRY 176_ EIKDI 181_ HVPPR 186_ VKESM 191_ QMQVE 196_ AERRK 201_ RATVL 206_ ESEGT 211_ RESAI 216_ NVAEG 221_ KKQAQ 226_ ILASE 231_ AEKAE 236_ QINQA 241_ AGEAS 246_ AVLAK 251_ AKAKA 256_ EAIRI 261_ LAAAL 266_ TQHNG 271_ DAAAS 276_ LTVAE 281_ QYVSA 286_ FSKLA 291_ KDSNT 296_ ILLPS 301_ NPGDV 306_ TSMVA 311_ QAMGV 316_ YGALT 321_ KAPVP 326_ GTPDS 331_ LSSGS 336_ SRDVQ 341_ GTDAS 346_ LDEEL 351_DRVKM
1: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation