Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3)
1_MAAGV 6_ AAWLP 11_ FARAA 16_ AIGWM 21_ PVANC 26_ PMPLA 31_ PADKN 36_ KRQDE 41_ LIVLN 46_ VSGRR 51_ FQTWR 56_ TTLER 61_ YPDTL 66_ LGSTE 71_ KEFFF 76_ NEDTK 81_ EYFFD 86_ RDPEV 91_ FRCVL 96_ NFYRT 101_ GKLHY 106_ PRYEC 111_ ISAYD 116_ DELAF 121_ YGILP 126_ EIIGD 131_ CCYEE 136_ YKDRK 141_ RENAE 146_ RLMDD 151_ NDSEN 156_ NQESM 161_ PSLSF 166_ RQTMW 171_ RAFEN 176_ PHTST 181_ LALVF 186_ YYVTG 191_ FFIAV 196_ SVITN 201_ VVETV 206_ PCGTV 211_ PGSKE 216_ LPCGE 221_ RYSVA 226_ FFCLD 231_ TACVM 236_ IFTVE 241_ YLLRL 246_ FAAPS 251_ RYRFI 256_ RSVMS 261_ IIDVV 266_ AIMPY 271_ YIGLV 276_ MTNNE 281_ DVSGA 286_ FVTLR 291_ VFRVF 296_ RIFKF 301_ SRHSQ 306_ GLRIL 311_ GYTLK 316_ SCASE 321_ LGFLL 326_ FSLTM 331_ AIIIF 336_ ATVMF 341_ YAEKG 346_ SSASK 351_ FTSIP 356_ ASFWY 361_ TIVTM 366_ TTLGY 371_ GDMVP 376_ KTIAG 381_ KIFGS 386_ ICSLS 391_ GVLVI 396_ ALPVP 401_ VIVSN 406_ FSRIY 411_ HQNQR 416_ ADKRR 421_ AQKKA 426_ RLARI 431_ RVAKT 436_ GSSNA 441_ YLHSK 446_ RNGLL 451_ NEALE 456_ LTGTP 461_ EEEHM 466_ GKTTS 471_ LIESQ 476_ HHHLL 481_ HCLEK 486_ TTGLS 491_ YLVDD 496_ PLLSV 501_ RTSTI 506_ KNHEF 511_ IDEQM 516_ FEQNC 521_ MESSM 526_ QNYPS 531_ TRSPS 536_ LSSHP 541_ GLTTT 546_ CCSRR 551_ SKKTT 556_ HLPNS 561_ NLPAT 566_ RLRSM 571_ QELST 576_ IHIQG 581_ SEQPS 586_ LTTSR 591_ SSLNL 596_ KADDG 601_ LRPNC 606_ KTSQI 611_ TTAII 616_ SIPTP 621_ PALTP 626_ EGESR 631_ PPPAS 636_ PGPNT 641_ NIPSI 646_ASNVV
1: Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed:10200233, PubMed:17187064, PubMed:21349352, PubMed:22457051, PubMed:23280837, PubMed:23280838, PubMed:34997220, PubMed:9843794). In cardiomyocytes, may generate the transient outward potassium current I(To) (By similarity). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation (PubMed:10200233, PubMed:17187064, PubMed:21349352, PubMed:22457051, PubMed:23280837, PubMed:23280838, PubMed:34997220, PubMed:9843794). Channel properties are modulated by interactions with regulatory subunits (PubMed:17187064, PubMed:34997220). Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation (PubMed:17187064, PubMed:34997220). Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics (PubMed:34997220)