F-box only protein 2
1_MDGDG 6_ DPESV 11_ GQPEE 16_ ASPEE 21_ QPEEA 26_ SAEEE 31_ RPEDQ 36_ QEEEA 41_ AAAAA 46_ YLDEL 51_ PEPLL 56_ LRVLA 61_ ALPAA 66_ ELVQA 71_ CRLVC 76_ LRWKE 81_ LVDGA 86_ PLWLL 91_ KCQQE 96_ GLVPE 101_ GGVEE 106_ ERDHW 111_ QQFYF 116_ LSKRR 121_ RNLLR 126_ NPCGE 131_ EDLEG 136_ WCDVE 141_ HGGDG 146_ WRVEE 151_ LPGDS 156_ GVEFT 161_ HDESV 166_ KKYFA 171_ SSFEW 176_ CRKAQ 181_ VIDLQ 186_ AEGYW 191_ EELLD 196_ TTQPA 201_ IVVKD 206_ WYSGR 211_ SDAGC 216_ LYELT 221_ VKLLS 226_ EHENV 231_ LAEFS 236_ SGQVA 241_ VPQDS 246_ DGGGW 251_ MEISH 256_ TFTDY 261_ GPGVR 266_ FVRFE 271_ HGGQD 276_ SVYWK 281_ GWFGA 286_ RVTNS 291_SVWVE
1: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity)