N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase)
1_MATST 6_ GRWLL 11_ LRLAL 16_ FGFLW 21_ EASGG 26_ LDSGA 31_ SRDDD 36_ LLLPY 41_ PRARA 46_ RLPRD 51_ CTRVR 56_ AGNRE 61_ HESWP 66_ PPPAT 71_ PGAGG 76_ LAVRT 81_ FVSHF 86_ RDRAV 91_ AGHLT 96_ RAVEP 101_ LRTFS 106_ VLEPG 111_ GPGGC 116_ AARRR 121_ ATVEE 126_ TARAA 131_ DCRVA 136_ QNGGF 141_ FRMNS 146_ GECLG 151_ NVVSD 156_ ERRVS 161_ SSGGL 166_ QNAQF 171_ GIRRD 176_ GTLVT 181_ GYLSE 186_ EEVLD 191_ TENPF 196_ VQLLS 201_ GVVWL 206_ IRNGS 211_ IYINE 216_ SQATE 221_ CDETQ 226_ ETGSF 231_ SKFVN 236_ VISAR 241_ TAIGH 246_ DRKGQ 251_ LVLFH 256_ ADGQT 261_ EQRGI 266_ NLWEM 271_ AEFLL 276_ KQDVV 281_ NAINL 286_ DGGGS 291_ ATFVL 296_ NGTLA 301_ SYPSD 306_ HCQDN 311_ MWRCP 316_ RQVST 321_ VVCVH 326_ EPRCQ 331_ PPDCH 336_ GHGTC 341_ VDGHC 346_ QCTGH 351_ FWRGP 356_ GCDEL 361_ DCGPS 366_ NCSQH 371_ GLCTE 376_ TGCRC 381_ DAGWT 386_ GSNCS 391_ EECPL 396_ GWHGP 401_ GCQRP 406_ CKCEH 411_ HCPCD 416_ PKTGN 421_ CSVSR 426_ VKQCL 431_ QPPEA 436_ TLRAG 441_ ELSFF 446_ TRTAW 451_ LALTL 456_ ALAFL 461_ LLIST 466_ AANLS 471_ LLLSR 476_ AERNR 481_ RLHGD 486_ YAYHP 491_ LQEMN 496_ GEPLA 501_ AEKEQ 506_PGGAH
1: Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases