Nocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein)
1_MFHSP 6_ RRLCS 11_ ALLQR 16_ DAPGL 21_ RRLPA 26_ PGLRR 31_ PLSPP 36_ AAVPR 41_ PASPR 46_ LLAAA 51_ SAASG 56_ AARSC 61_ SRTVC 66_ SMGTG 71_ TSRLY 76_ SALAK 81_ TLNSS 86_ AASQH 91_ PEYLV 96_ SPDPE 101_ HLEPI 106_ DPKEL 111_ LEECR 116_ AVLHT 121_ RPPRF 126_ QRDFV 131_ DLRTD 136_ CPSTH 141_ PPIRV 146_ MQWNI 151_ LAQAL 156_ GEGKD 161_ NFVQC 166_ PVEAL 171_ KWEER 176_ KCLIL 181_ EEILA 186_ YQPDI 191_ LCLQE 196_ VDHYF 201_ DTFQP 206_ LLSRL 211_ GYQGT 216_ FFPKP 221_ WSPCL 226_ DVEHN 231_ NGPDG 236_ CALFF 241_ LQNRF 246_ KLVNS 251_ ANIRL 256_ TAMTL 261_ KTNQV 266_ AIAQT 271_ LECKE 276_ SGRQF 281_ CIAVT 286_ HLKAR 291_ TGWER 296_ FRSAQ 301_ GCDLL 306_ QNLQN 311_ ITQGA 316_ KIPLI 321_ VCGDF 326_ NAEPT 331_ EEVYK 336_ HFASS 341_ SLNLN 346_ SAYKL 351_ LSADG 356_ QSEPP 361_ YTTWK 366_ IRTSG 371_ ECRHT 376_ LDYIW 381_ YSKHA 386_ LNVRS 391_ ALDLL 396_ TEEQI 401_ GPNRL 406_ PSFNY 411_ PSDHL 416_ SLVCD 421_ FSFTE 426_ESDGL
1: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity)