Lariat debranching enzyme (EC 3.1.-.-)
1_MRVAV 6_ AGCCH 11_ GELDK 16_ IYETL 21_ ALAER 26_ RGPGP 31_ VDLLL 36_ CCGDF 41_ QAVRN 46_ EADLR 51_ CMAVP 56_ PKYRH 61_ MQTFY 66_ RYYSG 71_ EKKAP 76_ VLTLF 81_ IGGNH 86_ EASNH 91_ LQELP 96_ YGGWV 101_ APNIY 106_ YLGLA 111_ GVVKY 116_ RGVRI 121_ GGISG 126_ IFKSH 131_ DYRKG 136_ HFECP 141_ PYNSS 146_ TIRSI 151_ YHVRN 156_ IEVYK 161_ LKQLK 166_ QPIDI 171_ FLSHD 176_ WPRSI 181_ YHYGN 186_ KKQLL 191_ KTKSF 196_ FRQEV 201_ ENNTL 206_ GSPAA 211_ SELLE 216_ HLKPT 221_ YWFSA 226_ HLHVK 231_ FAALM 236_ QHQAK 241_ DKGQT 246_ ARATK 251_ FLALD 256_ KCLPH 261_ RDFLQ 266_ ILEIE 271_ HDPSA 276_ PDYLE 281_ YDIEW 286_ LTILR 291_ ATDDL 296_ INVTG 301_ RLWNM 306_ PENNG 311_ LHARW 316_ DYSAT 321_ EEGMK 326_ EVLEK 331_ LNHDL 336_ KVPCN 341_ FSVTA 346_ ACYDP 351_ SKPQT 356_ QMQLI 361_ HRINP 366_ QTTEF 371_ CAQLG 376_ IIDIN 381_ VRLQK 386_ SKEEH 391_ HVCGE 396_ YEEQD 401_ DVESN 406_ DSGED 411_ QSEYN 416_ TDTSA 421_ LSSIN 426_ PDEIM 431_ LDEEE 436_ DEDSI 441_ VSAHS 446_ GMNTP 451_ SVEPS 456_ DQASE 461_ FSASF 466_ SDVRI 471_ LPGSM 476_ IVSSD 481_ DTVDS 486_ TIDRE 491_ GKPGG 496_ TVESG 501_ NGEDL 506_ TKVPL 511_ KRLSD 516_ EHEPE 521_ QRKKI 526_ KRRNQ 531_ AIYAA 536_VDDDD
1: Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:10982890, PubMed:16232320, PubMed:2435736). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem (PubMed:16232320, PubMed:29474921)