Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein)
1_MATAV 6_ ETEAC 11_ QPTDA 16_ SWESG 21_ GGGDD 26_ EMKQA 31_ LPELE 36_ SSQQN 41_ GGGGG 46_ LNIAE 51_ PSGGA 56_ GREEN 61_ AGAEA 66_ AQSLS 71_ HEQPQ 76_ DSSEA 81_ GAAAL 86_ PRGPE 91_ EPERP 96_ VRRSF 101_ QIPRK 106_ SREKK 111_ ALFQP 116_ LTPGS 121_ REFED 126_ VVNIL 131_ HSSYL 136_ EPTSV 141_ TNFNY 146_ RRACL 151_ VHNEL 156_ LEKEF 161_ TEKRR 166_ ELKFD 171_ GRLDK 176_ ELSES 181_ YAFLM 186_ VDRYQ 191_ VQTIC 196_ EKGLH 201_ VGQSK 206_ ITILG 211_ SPSMG 216_ VYLSR 221_ YADLL 226_ QANPL 231_ DTGAM 236_ GDVVI 241_ FKIMK 246_ GKIKS 251_ IYDPM 256_ GVKSL 261_ ESMLN 266_ KSALD 271_ PTPKH 276_ ECHVS 281_ KNANR 286_ ITSLL 291_ AYRAY 296_ ELTQY 301_ YFYEY 306_ GFDEL 311_ RRRPR 316_ HVCPY 321_ AVVSF 326_ TYKDD 331_ IQTPK 336_ FVPSS 341_ RSNSF 346_ NTDRN 351_ IDKYN 356_ YTLWK 361_ GQLLN 366_ KGKLL 371_ CYISL 376_ RSATR 381_ AFLPI 386_ KLPEK 391_ LDVET 396_ VMSID 401_ HLKQK 406_ IPPAL 411_ FYKET 416_ YLGPN 421_ EVLKN 426_ GMYCS 431_ LYEVV 436_ EKTRI 441_ GSNME 446_ SLLQK 451_ LDREK 456_ LVLVK 461_ PLGDR 466_ GYLFL 471_ LSPYQ 476_ MVPPY 481_ EYQTA 486_ KSRVL 491_ HALFL 496_ FQEPR 501_ SIVTS 506_ QKGST 511_ NAAPQ 516_ ERHES 521_ MPDVL 526_ KIAQF 531_ LQFSL 536_ IQCRK 541_ EFKNI 546_ SAINF 551_ HSVVE 556_ KYVSE 561_ FFKRG 566_ FGSGK 571_ REFIM 576_ FPYDS 581_ RLDDK 586_ KFLYS 591_ APRNK 596_ SHIDT 601_ CLHAY 606_ IFRPE 611_ VYQLP 616_ ICKLK 621_ ELFEE 626_ NRKLQ 631_ QFSPL 636_ SDYEG 641_ QEEEM 646_ NGTKM 651_ KFGKR 656_ NNSRG 661_ EAIIS 666_ GKQRS 671_ SHSLD 676_ YDKDR 681_ VKELI 686_ NLIQC 691_ RKKSV 696_ GGDSD 701_ TEDMR 706_ SKTVL 711_ KRKLE 716_ DLPEN 721_ MRKLA 726_ KTSNL 731_ SENCH 736_ LYEES 741_ PQPIG 746_ SLGHD 751_ ADLRR 756_ QQQDT 761_ CNSGI 766_ ADIHR 771_ LFNWL 776_ SETLA 781_ NARHS 786_ DASLT 791_ DTVNK 796_ ALGLS 801_ TDDAY 806_ EELRQ 811_ KHEYE 816_ LNSTP 821_ DKKDY 826_ EQPTC 831_ AKVEN 836_ AQFKG 841_ TQSLL 846_ LEVDA 851_ TSKYS 856_ VAIST 861_ SEVGT 866_ DHKLH 871_ LKEDP 876_ NLISV 881_ NNFED 886_ CSLCP 891_ SVPIE 896_ HGFRR 901_ QQSKS 906_ NNVEE 911_ TEIHW 916_ KLIPI 921_ TGGNA 926_ RSPED 931_ QLGKH 936_ GEKQT 941_ PGMKS 946_ PEEQL 951_ VCVPP 956_ QEAFP 961_ NDPRV 966_ INRQR 971_ SSDYQ 976_ FPSSP 981_ FTDTL 986_ KGTTE 991_ DDVLT 996_ GQVEE 1001_ QCVPA 1006_ AEAEP 1011_ PAVSE 1016_ TTERT 1021_ VLGEY 1026_ NLFSR 1031_ KIEEI 1036_ LKQKN 1041_ VSYVS 1046_ TVSTP 1051_ IFSTQ 1056_ EKMKR 1061_ LSEFI 1066_ YSKTS 1071_ KAGVQ 1076_ EFVDG 1081_ LHEKL 1086_ NTIII 1091_ KASAK 1096_ GGNLP 1101_ PVSPN 1106_ DSGAK 1111_ IASNP 1116_ LERHV 1121_ IPVSS 1126_ SDFNN 1131_ KHLLE 1136_ PLCSD 1141_ PLKDT 1146_ NSDEQ 1151_ HSTSA 1156_ LTEVE 1161_ MNQPQ 1166_ HATEL 1171_ MVTSD 1176_ HIVPG 1181_ DMARE 1186_ PVEET 1191_ TKSPS 1196_ DVNIS 1201_ AQPAL 1206_ SNFIS 1211_ QLEPE 1216_ VFNSL 1221_ VKIMK 1226_ DVQKN 1231_ TVKFY 1236_ IHEEE 1241_ ESVLC 1246_ KEIKE 1251_ YLIKL 1256_ GNTEC 1261_ HPEQF 1266_ LERRS 1271_ KLDKL 1276_ LIIIQ 1281_ NEDIA 1286_ GFIHK 1291_ IPGLV 1296_ TLKKL 1301_ PCVSF 1306_ AGVDS 1311_ LDDVK 1316_ NHTYN 1321_ ELFVS 1326_ GGFIV 1331_ SDESI 1336_ LNPEV 1341_ VTVEN 1346_ LKNFL 1351_ TFLEE 1356_ LSTPE 1361_ GKWQW 1366_ KVHCK 1371_ FQKKL 1376_ KELGR 1381_ LNAKA 1386_ LSLLT 1391_ LLNVY 1396_ QKKHL 1401_ VEILS 1406_ YHNCD 1411_ SQTRN 1416_ APELD 1421_ CLIRL 1426_ QAQNI 1431_ QQRHI 1436_ VFLTE 1441_ KNIKM 1446_ LSSYT 1451_ DNGIV 1456_ VATAE 1461_ DFMQN 1466_ FKNLV 1471_ GYHNS 1476_ ITEEN 1481_ LPQLG 1486_ ANENL 1491_ ESQSA 1496_ LLEND 1501_ EKDEE 1506_ DMSLD 1511_ SGDEI 1516_ SHIEV 1521_ CSNFH 1526_ SEIWE 1531_ KETKG 1536_ SRGTD 1541_ QKKNT 1546_ QIELQ 1551_ SSPDV 1556_ QNSLL 1561_ EDKTY 1566_ LDSEE 1571_ RTSID 1576_ IVCSE 1581_ GENSN 1586_ STEQD 1591_ SYSNF 1596_ QVYHS 1601_ QLNMS 1606_ HQFSH 1611_ FNVLT 1616_ HQTFL 1621_ GTPYA 1626_ LSSSQ 1631_ SQENE 1636_ NYFLS 1641_ AYTES 1646_ LDRDK 1651_ SPPPL 1656_ SWGKS 1661_DSSRP
1: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity)