Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha)
1_MEGLA 6_ GYVYK 11_ AASEG 16_ KVLTL 21_ AALLL 26_ NRSES 31_ DIRYL 36_ LGYVS 41_ QQGGQ 46_ RSTPL 51_ IIAAR 56_ NGHAK 61_ VVRLL 66_ LEHYR 71_ VQTQQ 76_ TGTVR 81_ FDGYV 86_ IDGAT 91_ ALWCA 96_ AGAGH 101_ FEVVK 106_ LLVSH 111_ GANVN 116_ HTTVT 121_ NSTPL 126_ RAACF 131_ DGRLD 136_ IVKYL 141_ VENNA 146_ NISIA 151_ NKYDN 156_ TCLMI 161_ AAYKG 166_ HTDVV 171_ RYLLE 176_ QRADP 181_ NAKAH 186_ CGATA 191_ LHFAA 196_ EAGHI 201_ DIVKE 206_ LIKWR 211_ AAIVV 216_ NGHGM 221_ TPLKV 226_ AAESC 231_ KADVV 236_ ELLLS 241_ HADCD 246_ RRSRI 251_ EALEL 256_ LGASF 261_ ANDRE 266_ NYDII 271_ KTYHY 276_ LYLAM 281_ LERFQ 286_ DGDNI 291_ LEKEV 296_ LPPIH 301_ AYGNR 306_ TECRN 311_ PQELE 316_ SIRQD 321_ RDALH 326_ MEGLI 331_ VRERI 336_ LGADN 341_ IDVSH 346_ PIIYR 351_ GAVYA 356_ DNMEF 361_ EQCIK 366_ LWLHA 371_ LHLRQ 376_ KGNRN 381_ THKDL 386_ LRFAQ 391_ VFSQM 396_ IHLNE 401_ TVKAP 406_ DIECV 411_ LRCSV 416_ LEIEQ 421_ SMNRV 426_ KNISD 431_ ADVHN 436_ AMDNY 441_ ECNLY 446_ TFLYL 451_ VCIST 456_ KTQCS 461_ EEDQC 466_ KINKQ 471_ IYNLI 476_ HLDPR 481_ TREGF 486_ TLLHL 491_ AVNSN 496_ TPVDD 501_ FHTND 506_ VCSFP 511_ NALVT 516_ KLLLD 521_ CGAEV 526_ NAVDN 531_ EGNSA 536_ LHIIV 541_ QYNRP 546_ ISDFL 551_ TLHSI 556_ IISLV 561_ EAGAH 566_ TDMTN 571_ KQNKT 576_ PLDKS 581_ TTGVS 586_ EILLK 591_ TQMKM 596_ SLKCL 601_ AARAV 606_ RANDI 611_ NYQDQ 616_ IPRTL 621_EEFVG
1: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33398168, PubMed:33398170). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33398168, PubMed:33398170). The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation (PubMed:33398168, PubMed:33398170). Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS) (By similarity). Mechanistically, recognizes and binds reduced FNIP1 through two interface zinc ions, which act as a molecular glue that recruit reduced FNIP1 to FEM1B (By similarity). Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity (PubMed:24076122). Promotes ubiquitination and degradation of ANKRD37 (By similarity). Promotes ubiquitination and degradation of SLBP (PubMed:28118078). Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (PubMed:10542291). Also involved in glucose homeostasis in pancreatic islet (By similarity). May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (PubMed:19330022)