F-box only protein 10
1_MEAGG 6_ LPLEL 11_ WRMIL 16_ AYLHL 21_ PDLGR 26_ CSLVC 31_ RAWYE 36_ LILSL 41_ DSTRW 46_ RQLCL 51_ GCTEC 56_ RHPNW 61_ PNQPD 66_ VEPES 71_ WREAF 76_ KQHYL 81_ ASKTW 86_ TKNAL 91_ DLESS 96_ ICFSL 101_ FRRRR 106_ ERRTL 111_ SVGPG 116_ REFDS 121_ LGSAL 126_ AMASL 131_ YDRIV 136_ LFPGV 141_ YEEQG 146_ EIILK 151_ VPVEI 156_ VGQGK 161_ LGEVA 166_ LLASI 171_ DQHCS 176_ TTRLC 181_ NLVFT 186_ PAWFS 191_ PIMYK 196_ TTSGH 201_ VQFDN 206_ CNFEN 211_ GHIQV 216_ HGPGT 221_ CQVKF 226_ CTFKN 231_ THIFL 236_ HNVPL 241_ CVLEN 246_ CEFVG 251_ SENNS 256_ VTVEG 261_ HPSAD 266_ KNWAY 271_ KYLLG 276_ LIKSS 281_ PTFLP 286_ TEDSD 291_ FLMSL 296_ DLESR 301_ DQAWS 306_ PKTCD 311_ IVIEG 316_ SQSPT 321_ SPASS 326_ SPKPG 331_ SKAGS 336_ QEAEV 341_ GSDGE 346_ RVAQT 351_ PDSSD 356_ GGLSP 361_ SGEDE 366_ DEDQL 371_ MYRLS 376_ YQVQG 381_ PRPVL 386_ GGSFL 391_ GPPLP 396_ GASIQ 401_ LPSCL 406_ VLNSL 411_ QQELQ 416_ KDKEA 421_ MALAN 426_ SVQGC 431_ LIRKC 436_ LFRDG 441_ KGGVF 446_ VCSHG 451_ RAKME 456_ GNIFR 461_ NLTYA 466_ VRCIH 471_ NSKII 476_ MLRND 481_ IYRCR 486_ ASGIF 491_ LRLEG 496_ GGLIA 501_ GNNIY 506_ HNAEA 511_ GVDIR 516_ KKSNP 521_ LILCN 526_ QIHHG 531_ LRSGI 536_ VVLGN 541_ GKGII 546_ RNNQI 551_ FSNKE 556_ AGIYI 561_ LYHGN 566_ PVVSG 571_ NHIFK 576_ GRAAG 581_ IAVNE 586_ NGKGL 591_ ITENV 596_ IRENQ 601_ WGGVD 606_ IRRGG 611_ IPVLR 616_ SNLIC 621_ FGYSD 626_ GVVVG 631_ DEGKG 636_ LIEGN 641_ TIYAN 646_ KGCGV 651_ WMMSS 656_ SLPHV 661_ TSNHV 666_ SYNGL 671_ YGVAV 676_ FSQKD 681_ GSSEL 686_ PRGHR 691_ AQENF 696_ SEDGD 701_ AILWE 706_ TELEK 711_ EDDPL 716_ RRPIT 721_ IALVE 726_ SNSIN 731_ HNGAS 736_ GLYVQ 741_ SSEAL 746_ HVITN 751_ VIHAN 756_ GDRGI 761_ TVAQS 766_ SQPTR 771_ VANNS 776_ ISCNR 781_ QSGVK 786_ VEAQC 791_ KVELR 796_ GNGIY 801_ DNRGH 806_ GIITK 811_ GDSTI 816_ VIEND 821_ IIGNR 826_ GSGLQ 831_ LLPRS 836_ DTKVI 841_ KNRIH 846_ SFRAY 851_ GIAVR 856_ GRAKA 861_ LVQEN 866_ IIFQG 871_ KTSKT 876_ IFQQI 881_ SNNRE 886_ CIMQN 891_ NKFLV 896_ FKKKS 901_ DTWRL 906_ VNPPA 911_ RPHLE 916_ NSLRR 921_ PSAAH 926_ NGQKV 931_ TAMAT 936_ RITAR 941_ VEGGY 946_ HSNRS 951_VFCTI
1: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation (PubMed:28515150). Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling (PubMed:31570756)