F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57)
1_MPDII 6_ WVFPP 11_ QAEAE 16_ EDCHS 21_ DTVRA 26_ DDDEE 31_ NESPA 36_ ETDLQ 41_ AQLQM 46_ FRAQW 51_ MFELA 56_ PGVSS 61_ SNLEN 66_ RPCRA 71_ ARGSL 76_ QKTSA 81_ DTKGK 86_ QEQAK 91_ EEKAR 96_ ELFLK 101_ AVEEE 106_ QNGAL 111_ YEAIK 116_ FYRRA 121_ MQLVP 126_ DIEFK 131_ ITYTR 136_ SPDGD 141_ GVGNS 146_ YIEDN 151_ DDDSK 156_ MADLL 161_ SYFQQ 166_ QLTFQ 171_ ESVLK 176_ LCQPE 181_ LESSQ 186_ IHISV 191_ LPMEV 196_ LMYIF 201_ RWVVS 206_ SDLDL 211_ RSLEQ 216_ LSLVC 221_ RGFYI 226_ CARDP 231_ EIWRL 236_ ACLKV 241_ WGRSC 246_ IKLVP 251_ YTSWR 256_ EMFLE 261_ RPRVR 266_ FDGVY 271_ ISKTT 276_ YIRQG 281_ EQSLD 286_ GFYRA 291_ WHQVE 296_ YYRYI 301_ RFFPD 306_ GHVMM 311_ LTTPE 316_ EPQSI 321_ VPRLR 326_ TRNTR 331_ TDAIL 336_ LGHYR 341_ LSQDT 346_ DNQTK 351_ VFAVI 356_ TKKKE 361_ EKPLD 366_ YKYRY 371_ FRRVP 376_ VQEAD 381_ QSFHV 386_ GLQLC 391_ SSGHQ 396_ RFNKL 401_ IWIHH 406_ SCHIT 411_ YKSTG 416_ ETAVS 421_ AFEID 426_ KMYTP 431_ LFFAR 436_ VRSYT 441_AFSER
1: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability (PubMed:23263282, PubMed:34480022). Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1 (PubMed:23263282). Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (PubMed:34480022). Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (By similarity)