F-box only protein 3
1_MAAME 6_ TETAP 11_ LTLES 16_ LPTDP 21_ LLLIL 26_ SFLDY 31_ RDLIN 36_ CCYVS 41_ RRLSQ 46_ LSSHD 51_ PLWRR 56_ HCKKY 61_ WLISE 66_ EEKTQ 71_ KNQCW 76_ KSLFI 81_ DTYSD 86_ VGRYI 91_ DHYAA 96_ IKKAW 101_ DDLKK 106_ YLEPR 111_ CPRMV 116_ LSLKE 121_ GAREE 126_ DLDAV 131_ EAQIG 136_ CKLPD 141_ DYRCS 146_ YRIHN 151_ GQKLV 156_ VPGLL 161_ GSMAL 166_ SNHYR 171_ SEDLL 176_ DVDTA 181_ AGGFQ 186_ QRQGL 191_ KYCLP 196_ LTFCI 201_ HTGLS 206_ QYIAV 211_ EAAEG 216_ RNKNE 221_ VFYQC 226_ PDQMA 231_ RNPAA 236_ IDMFI 241_ IGATF 246_ TDWFT 251_ SYVKN 256_ VVSGG 261_ FPIIR 266_ DQIFR 271_ YVHDP 276_ ECVAT 281_ TGDIT 286_ VSVST 291_ SFLPE 296_ LSSVH 301_ PPHYF 306_ FTYRI 311_ RIEMS 316_ KDALP 321_ EKACQ 326_ LDSRY 331_ WRITN 336_ AKGDV 341_ EEVQG 346_ PGVVG 351_ EFPII 356_ SPGRV 361_ YEYTS 366_ CTTFS 371_ TTSGY 376_ MEGYY 381_ TFHFL 386_ YFKDK 391_ IFNVA 396_ IPRFH 401_ MACPT 406_ FRVSI 411_ ARLEM 416_ GPDEY 421_ EEMEE 426_ EEEEE 431_ EEEDE 436_ DDDSA 441_ DMDES 446_ DEDDE 451_ EERRR 456_ RVFDV 461_ PIRRR 466_RCSRL
1: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:18809579, PubMed:26037928). Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome (PubMed:18809579). In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented (PubMed:18809579). PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (PubMed:18809579). The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS) (PubMed:26037928, PubMed:27010866). The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (PubMed:27010866)
2: (Microbial infection) Associates with the Rift valley fever virus NSs to form a remodeled E3 ligase that triggers efficient proteasomal degradation of targeted proteins. The filamentous E3 ligase targets the TFIIH complex leading to robust inhibition of antiviral immunity and enhances viral pathogenesis