Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (Neurally-enriched homolog of PTB) (PTB-like protein)
1_MDGIV 6_ TEVAV 11_ GVKRG 16_ SDELL 21_ SGSVL 26_ SSPNS 31_ NMSSM 36_ VVTAN 41_ GNDSK 46_ KFKGE 51_ DKMDG 56_ APSRV 61_ LHIRK 66_ LPGEV 71_ TETEV 76_ IALGL 81_ PFGKV 86_ TNILM 91_ LKGKN 96_ QAFLE 101_ LATEE 106_ AAITM 111_ VNYYS 116_ AVTPH 121_ LRNQP 126_ IYIQY 131_ SNHKE 136_ LKTDN 141_ TLNQR 146_ AQAVL 151_ QAVTA 156_ VQTAN 161_ TPLSG 166_ TTVSE 171_ SAVTP 176_ AQSPV 181_ LRIII 186_ DNMYY 191_ PVTLD 196_ VLHQI 201_ FSKFG 206_ AVLKI 211_ ITFTK 216_ NNQFQ 221_ ALLQY 226_ GDPVN 231_ AQQAK 236_ LALDG 241_ QNIYN 246_ ACCTL 251_ RIDFS 256_ KLVNL 261_ NVKYN 266_ NDKSR 271_ DYTRP 276_ DLPSG 281_ DGQPA 286_ LDPAI 291_ AAAFA 296_ KETSL 301_ LAVPG 306_ ALSPL 311_ AIPNA 316_ AAAAA 321_ AAAAG 326_ RVGMP 331_ GVSAG 336_ GNTVL 341_ LVSNL 346_ NEEMV 351_ TPQSL 356_ FTLFG 361_ VYGDV 366_ QRVKI 371_ LYNKK 376_ DSALI 381_ QMADG 386_ NQSQL 391_ AMNHL 396_ NGQKM 401_ YGKII 406_ RVTLS 411_ KHQTV 416_ QLPRE 421_ GLDDQ 426_ GLTKD 431_ FGNSP 436_ LHRFK 441_ KPGSK 446_ NFQNI 451_ FPPSA 456_ TLHLS 461_ NIPPS 466_ VAEED 471_ LRTLF 476_ ANTGG 481_ TVKAF 486_ KFFQD 491_ HKMAL 496_ LQMAT 501_ VEEAI 506_ QALID 511_ LHNYN 516_ LGENH 521_ HLRVS 526_FSKST
1: RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation
2: Reduced affinity for RNA