F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
1_MEPDS 6_ VIEDK 11_ TIELM 16_ CSVPR 21_ SLWLG 26_ CANLV 31_ ESMCA 36_ LSCLQ 41_ SMPSV 46_ RCLQI 51_ SNGTS 56_ SVIVS 61_ RKRPS 66_ EGNYQ 71_ KEKDL 76_ CIKYF 81_ DQWSE 86_ SDQVE 91_ FVEHL 96_ ISRMC 101_ HYQHG 106_ HINSY 111_ LKPML 116_ QRDFI 121_ TALPE 126_ QGLDH 131_ IAENI 136_ LSYLD 141_ ARSLC 146_ AAELV 151_ CKEWQ 156_ RVISE 161_ GMLWK 166_ KLIER 171_ MVRTD 176_ PLWKG 181_ LSERR 186_ GWDQY 191_ LFKNR 196_ PTDGP 201_ PNSFY 206_ RSLYP 211_ KIIQD 216_ IETIE 221_ SNWRC 226_ GRHNL 231_ QRIQC 236_ RSENS 241_ KGVYC 246_ LQYDD 251_ EKIIS 256_ GLRDN 261_ SIKIW 266_ DKTSL 271_ ECLKV 276_ LTGHT 281_ GSVLC 286_ LQYDE 291_ RVIVT 296_ GSSDS 301_ TVRVW 306_ DVNTG 311_ EVLNT 316_ LIHHN 321_ EAVLH 326_ LRFSN 331_ GLMVT 336_ CSKDR 341_ SIAVW 346_ DMASA 351_ TDITL 356_ RRVLV 361_ GHRAA 366_ VNVVD 371_ FDDKY 376_ IVSAS 381_ GDRTI 386_ KVWST 391_ STCEF 396_ VRTLN 401_ GHKRG 406_ IACLQ 411_ YRDRL 416_ VVSGS 421_ SDNTI 426_ RLWDI 431_ ECGAC 436_ LRVLE 441_ GHEEL 446_ VRCIR 451_ FDNKR 456_ IVSGA 461_ YDGKI 466_ KVWDL 471_ QAALD 476_ PRAPA 481_ STLCL 486_ RTLVE 491_ HSGRV 496_ FRLQF 501_ DEFQI 506_ ISSSH 511_ DDTIL 516_ IWDFL 521_ NVPPS 526_ AQNET 531_ RSPSR 536_TYTYI
1: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10437795, PubMed:10648623, PubMed:11158290, PubMed:19966869, PubMed:20347421, PubMed:22017875, PubMed:22017876, PubMed:36608670). Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S (PubMed:10437795, PubMed:10648623, PubMed:19966869, PubMed:20347421, PubMed:22017875, PubMed:22017876, PubMed:36608670). SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation (PubMed:10321728). SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription (PubMed:10321728, PubMed:10437795, PubMed:10644755, PubMed:20347421). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (PubMed:11158290). SCF(FBXW11) mediates the ubiquitination of IFNAR1 (PubMed:14532120, PubMed:15337770). SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1 (PubMed:18575781). Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint (PubMed:14603323). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2 (PubMed:15917222). SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262). SCF(FBXW11) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (PubMed:22017875, PubMed:22017876, PubMed:36608670)
2: (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action