F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3)
1_MVFSN 6_ NDEGL 11_ INKKL 16_ PKELL 21_ LRIFS 26_ FLDIV 31_ TLCRC 36_ AQISK 41_ AWNIL 46_ ALDGS 51_ NWQRI 56_ DLFNF 61_ QTDVE 66_ GRVVE 71_ NISKR 76_ CGGFL 81_ RKLSL 86_ RGCIG 91_ VGDSS 96_ LKTFA 101_ QNCRN 106_ IEHLN 111_ LNGCT 116_ KITDS 121_ TCYSL 126_ SRFCS 131_ KLKHL 136_ DLTSC 141_ VSITN 146_ SSLKG 151_ ISEGC 156_ RNLEY 161_ LNLSW 166_ CDQIT 171_ KDGIE 176_ ALVRG 181_ CRGLK 186_ ALLLR 191_ GCTQL 196_ EDEAL 201_ KHIQN 206_ YCHEL 211_ VSLNL 216_ QSCSR 221_ ITDEG 226_ VVQIC 231_ RGCHR 236_ LQALC 241_ LSGCS 246_ NLTDA 251_ SLTAL 256_ GLNCP 261_ RLQIL 266_ EAARC 271_ SHLTD 276_ AGFTL 281_ LARNC 286_ HELEK 291_ MDLEE 296_ CILIT 301_ DSTLI 306_ QLSIH 311_ CPKLQ 316_ ALSLS 321_ HCELI 326_ TDDGI 331_ LHLSN 336_ STCGH 341_ ERLRV 346_ LELDN 351_ CLLIT 356_ DVALE 361_ HLENC 366_ RGLER 371_ LELYD 376_ CQQVT 381_ RAGIK 386_ RMRAQ 391_ LPHVK 396_ VHAYF 401_ APVTP 406_ PTAVA 411_ GSGQR 416_LCRCC
1: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:22020328, PubMed:22323446). Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin (PubMed:22020328, PubMed:22323446). This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin (PubMed:22020328, PubMed:22323446). Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity). The SCF(FBXL2) complex acts as a regulator of inflammation by mediating ubiquitination and degradation of TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6) (By similarity). The SCF(FBXL2) complex acts as a negative regulator of the NLRP3 inflammasome by mediating ubiquitination and degradation of NLRP3 (PubMed:26037928)