TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
1_MASDS 6_ PARSL 11_ DEIDL 16_ SALRD 21_ PAGIF 26_ ELVEL 31_ VGNGT 36_ YGQVY 41_ KGRHV 46_ KTGQL 51_ AAIKV 56_ MDVTG 61_ DEEEE 66_ IKQEI 71_ NMLKK 76_ YSHHR 81_ NIATY 86_ YGAFI 91_ KKNPP 96_ GMDDQ 101_ LWLVM 106_ EFCGA 111_ GSVTD 116_ LIKNT 121_ KGNTL 126_ KEEWI 131_ AYICR 136_ EILRG 141_ LSHLH 146_ QHKVI 151_ HRDIK 156_ GQNVL 161_ LTENA 166_ EVKLV 171_ DFGVS 176_ AQLDR 181_ TVGRR 186_ NTFIG 191_ TPYWM 196_ APEVI 201_ ACDEN 206_ PDATY 211_ DFKSD 216_ LWSLG 221_ ITAIE 226_ MAEGA 231_ PPLCD 236_ MHPMR 241_ ALFLI 246_ PRNPA 251_ PRLKS 256_ KKWSK 261_ KFQSF 266_ IESCL 271_ VKNHS 276_ QRPAT 281_ EQLMK 286_ HPFIR 291_ DQPNE 296_ RQVRI 301_ QLKDH 306_ IDRTK 311_ KKRGE 316_ KDETE 321_ YEYSG 326_ SEEEE 331_ EENDS 336_ GEPSS 341_ ILNLP 346_ GESTL 351_ RRDFL 356_ RLQLA 361_ NKERS 366_ EALRR 371_ QQLEQ 376_ QQREN 381_ EEHKR 386_ QLLAE 391_ RQKRI 396_ EEQKE 401_ QRRRL 406_ EEQQR 411_ REKEL 416_ RKQQE 421_ REQRR 426_ HYEEQ 431_ MRREE 436_ ERRRA 441_ EHEQE 446_ YIRRQ 451_ LEEEQ 456_ RQLEI 461_ LQQQL 466_ LHEQA 471_ LLLEY 476_ KRKQL 481_ EEQRQ 486_ AERLQ 491_ RQLKQ 496_ ERDYL 501_ VSLQH 506_ QRQEQ 511_ RPVEK 516_ KPLYH 521_ YKEGM 526_ SPSEK 531_ PAWAK 536_ EVEER 541_ SRLNR 546_ QSSPA 551_ MPHKV 556_ ANRIS 561_ DPNLP 566_ PRSES 571_ FSISG 576_ VQPAR 581_ TPPML 586_ RPVDP 591_ QIPHL 596_ VAVKS 601_ QGPAL 606_ TASQS 611_ VHEQP 616_ TKGLS 621_ GFQEA 626_ LNVTS 631_ HRVEM 636_ PRQNS 641_ DPTSE 646_ NPPLP 651_ TRIEK 656_ FDRSS 661_ WLRQE 666_ EDIPP 671_ KVPQR 676_ TTSIS 681_ PALAR 686_ KNSPG 691_ NGSAL 696_ GPRLG 701_ SQPIR 706_ ASNPD 711_ LRRTE 716_ PILES 721_ PLQRT 726_ SSGSS 731_ SSSST 736_ PSSQP 741_ SSQGG 746_ SQPGS 751_ QAGSS 756_ ERTRV 761_ RANSK 766_ SEGSP 771_ VLPHE 776_ PAKVK 781_ PEESR 786_ DITRP 791_ SRPAS 796_ YKKAI 801_ DEDLT 806_ ALAKE 811_ LRELR 816_ IEETN 821_ RPMKK 826_ VTDYS 831_ SSSEE 836_ SESSE 841_ EEEED 846_ GESET 851_ HDGTV 856_ AVSDI 861_ PRLIP 866_ TGAPG 871_ SNEQY 876_ NVGMV 881_ GTHGL 886_ ETSHA 891_ DSFSG 896_ SISRE 901_ GTLMI 906_ RETSG 911_ EKKRS 916_ GHSDS 921_ NGFAG 926_ HINLP 931_ DLVQQ 936_ SHSPA 941_ GTPTE 946_ GLGRV 951_ STHSQ 956_ EMDSG 961_ TEYGM 966_ GSSTK 971_ ASFTP 976_ FVDPR 981_ VYQTS 986_ PTDED 991_ EEDEE 996_ SSAAA 1001_ LFTSE 1006_ LLRQE 1011_ QAKLN 1016_ EARKI 1021_ SVVNV 1026_ NPTNI 1031_ RPHSD 1036_ TPEIR 1041_ KYKKR 1046_ FNSEI 1051_ LCAAL 1056_ WGVNL 1061_ LVGTE 1066_ NGLML 1071_ LDRSG 1076_ QGKVY 1081_ NLINR 1086_ RRFQQ 1091_ MDVLE 1096_ GLNVL 1101_ VTISG 1106_ KKNKL 1111_ RVYYL 1116_ SWLRN 1121_ RILHN 1126_ DPEVE 1131_ KKQGW 1136_ ITVGD 1141_ LEGCI 1146_ HYKVV 1151_ KYERI 1156_ KFLVI 1161_ ALKNA 1166_ VEIYA 1171_ WAPKP 1176_ YHKFM 1181_ AFKSF 1186_ ADLQH 1191_ KPLLV 1196_ DLTVE 1201_ EGQRL 1206_ KVIFG 1211_ SHTGF 1216_ HVIDV 1221_ DSGNS 1226_ YDIYI 1231_ PSHIQ 1236_ GNITP 1241_ HAIVI 1246_ LPKTD 1251_ GMEML 1256_ VCYED 1261_ EGVYV 1266_ NTYGR 1271_ ITKDV 1276_ VLQWG 1281_ EMPTS 1286_ VAYIH 1291_ SNQIM 1296_ GWGEK 1301_ AIEIR 1306_ SVETG 1311_ HLDGV 1316_ FMHKR 1321_ AQRLK 1326_ FLCER 1331_ NDKVF 1336_ FASVR 1341_ SGGSS 1346_ QVFFM 1351_TLNRN
1: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443)