DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)
1_MPGID 6_ KLPIE 11_ ETLED 16_ SPQTR 21_ SLLGV 26_ FEEDA 31_ TAISN 36_ YMNQL 41_ YQAMH 46_ RIYDA 51_ QNELS 56_ AATHL 61_ TSKLL 66_ KEYEK 71_ QRFPL 76_ GGDDE 81_ VMSST 86_ LQQFS 91_ KVIDE 96_ LSSCH 101_ AVLST 106_ QLADA 111_ MMFPI 116_ TQFKE 121_ RDLKE 126_ ILTLK 131_ EVFQI 136_ ASNDH 141_ DAAIN 146_ RYSRL 151_ SKKRE 156_ NDKVK 161_ YEVTE 166_ DVYTS 171_ RKKQH 176_ QTMMH 181_ YFCAL 186_ NTLQY 191_ KKKIA 196_ LLEPL 201_ LGYMQ 206_ AQISF 211_ FKMGS 216_ ENLNE 221_ QLEEF 226_ LANIG 231_ TSVQN 236_ VRREM 241_ DSDIE 246_ TMQQT 251_ IEDLE 256_ VASDP 261_ LYVPD 266_ PDPTK 271_ FPVNR 276_ NLTRK 281_ AGYLN 286_ ARNKT 291_ GLVSS 296_ TWDRQ 301_ FYFTQ 306_ GGNLM 311_ SQARG 316_ DVAGG 321_ LAMDI 326_ DNCSV 331_ MAVDC 336_ EDRRY 341_ CFQIT 346_ SFDGK 351_ KSSIL 356_ QAESK 361_ KDHEE 366_ WICTI 371_ NNISK 376_ QIYLS 381_ ENPEE 386_ TAARV 391_ NQSAL 396_ EAVTP 401_ SPSFQ 406_ QRHES 411_ LRPAA 416_ GQSRP 421_ PTART 426_ SSSGS 431_ LGSES 436_ TNLAA 441_ LSLDS 446_ LVAPD 451_ TPIQF 456_ DIISP 461_ VCEDQ 466_ PGQAK 471_ AFGQG 476_ GRRTN 481_ PFGES 486_ GGSTK 491_ SETED 496_ SILHQ 501_ LFIVR 506_ FLGSM 511_ EVKSD 516_ DHPDV 521_ VYETM 526_ RQILA 531_ ARAIH 536_ NIFRM 541_ TESHL 546_ LVTCD 551_ CLKLI 556_ DPQTQ 561_ VTRLT 566_ FPLPC 571_ VVLYA 576_ THQEN 581_ KRLFG 586_ FVLRT 591_ SSGRS 596_ ESNLS 601_ SVCYI 606_ FESNN 611_ EGEKI 616_ CDSVG 621_ LAKQI 626_ ALHAE 631_ LDRRA 636_ SEKQK 641_ EIERV 646_ KEKQQ 651_ KELNK 656_ QKQIE 661_ KDLEE 666_ QSRLI 671_ AASSR 676_ PNQAS 681_ SEGQF 686_ VVLSS 691_ SQSEE 696_ SDLGE 701_GGKKR
1: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865)