Endogenous retrovirus group K member 9 Env polyprotein (EnvK4 protein) (Envelope polyprotein) (HERV-K(C6) envelope protein) (HERV-K109 envelope protein) (HERV-K_6q14.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
1_MNPSE 6_ MQRKA 11_ PPRRR 16_ RHRNR 21_ APLTH 26_ KMNKM 31_ VTSEE 36_ QMKLP 41_ STKKA 46_ EPPTW 51_ AQLKK 56_ LTQLA 61_ TKYLE 66_ NTKVT 71_ QTPES 76_ MLLAA 81_ LMIVS 86_ MVVSL 91_ PMPAG 96_ AAAAN 101_ YTNWA 106_ YVPFP 111_ PLIRA 116_ VTWMD 121_ NPIEV 126_ YVNDS 131_ VWVPG 136_ PIDDR 141_ CPAKP 146_ EEEGM 151_ MINIS 156_ IGYRY 161_ PICLG 166_ RAPGC 171_ LMPAV 176_ QNWLV 181_ EVPIV 186_ SPICR 191_ FTYHM 196_ VSGMS 201_ LRPRV 206_ NYLQD 211_ FSYQR 216_ SLKFR 221_ PKGKP 226_ CPKEI 231_ PKESK 236_ NTEVL 241_ VWEEC 246_ VANSA 251_ VILQN 256_ NEFGT 261_ IIDWT 266_ PQGQF 271_ YHNCS 276_ GQTQS 281_ CPSAQ 286_ VSPAV 291_ DSDLT 296_ ESLDK 301_ HKHKK 306_ LQSFY 311_ PWEWG 316_ EKGIS 321_ TPRPK 326_ IISPV 331_ SGPEH 336_ PELWR 341_ LTVAS 346_ HHIRI 351_ WSGNQ 356_ TLETR 361_ DRKPF 366_ YTVDL 371_ NSSLT 376_ LPLQS 381_ CVKPP 386_ YMLVV 391_ GNIVI 396_ KPDSQ 401_ TITCE 406_ NCRLL 411_ TCIDS 416_ TFNWQ 421_ HRILL 426_ VRARE 431_ GVWIP 436_ VSMDR 441_ PWEAS 446_ PSIHI 451_ LTEVL 456_ KGVLN 461_ RSKRF 466_ IFTLI 471_ AVIMG 476_ LIAVT 481_ ATAAV 486_ AGVAL 491_ HSSVQ 496_ SVNFV 501_ NDGQK 506_ NSTRL 511_ WNSQS 516_ SIDQK 521_ LANQI 526_ NDLRQ 531_ TVIWM 536_ GDRLM 541_ SLEHR 546_ FQLQC 551_ DWNTS 556_ DFCIT 561_ PQIYN 566_ ESEHH 571_ WDMVR 576_ RHLQG 581_ REDNL 586_ TLDIS 591_ KLKEQ 596_ IFEAS 601_ KAHLN 606_ LVPGT 611_ EAIAG 616_ VADGL 621_ ANLNP 626_ VTWVK 631_ TIGST 636_ TIINL 641_ ILILV 646_ CLFCL 651_ LLVCR 656_ CTQQL 661_ RRDSD 666_ HRERA 671_ MMTMA 676_ VLSKR 681_ KGGNV 686_ GKSKR 691_DQIVT
1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties
2: SU mediates receptor recognition
3: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)