Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1)
1_MSVQS 6_ SSGSL 11_ EGPPS 16_ WSQLS 21_ TSPTP 26_ GSAAA 31_ ARSLL 36_ NHTPP 41_ SGRPR 46_ EGAMD 51_ ELHSL 56_ DPRRQ 61_ ELLEA 66_ RFTGV 71_ ASGST 76_ GSTGS 81_ CSVGA 86_ KASTN 91_ NESSN 96_ HSFGS 101_ LGSLS 106_ DKESE 111_ TPEKK 116_ QSESS 121_ RGRKR 126_ KAENQ 131_ NESSQ 136_ GKSIG 141_ GRGHK 146_ ISDYF 151_ EYQGG 156_ NGSSP 161_ VRGIP 166_ PAIRS 171_ PQNSH 176_ SHSTP 181_ SSSVR 186_ PNSPS 191_ PTALA 196_ FGDHP 201_ IVQPK 206_ QLSFK 211_ IIQTD 216_ LTMLK 221_ LAALE 226_ SNKIQ 231_ DLEKK 236_ EGRID 241_ DLLRA 246_ NCDLR 251_ RQIDE 256_ QQKLL 261_ EKYKE 266_ RLNKC 271_ ISMSK 276_ KLLIE 281_ KSTQE 286_ KLSSR 291_ EKSMQ 296_ DRLRL 301_ GHFTT 306_ VRHGA 311_ SFTEQ 316_ WTDGF 321_ AFQNL 326_ VKQQE 331_ WVNQQ 336_ REDIE 341_ RQRKL 346_ LAKRK 351_ PPTAN 356_ NSQAP 361_ STNSE 366_ PKQRK 371_ NKAVN 376_ GAEND 381_ PFVRP 386_ NLPQL 391_ LTLAE 396_ YHEQE 401_ EIFKL 406_ RLGHL 411_ KKEEA 416_ EIQAE 421_ LERLE 426_ RVRNL 431_ HIREL 436_ KRINN 441_ EDNSQ 446_ FKDHP 451_ TLNER 456_ YLLLH 461_ LLGRG 466_ GFSEV 471_ YKAFD 476_ LYEQR 481_ YAAVK 486_ IHQLN 491_ KSWRD 496_ EKKEN 501_ YHKHA 506_ CREYR 511_ IHKEL 516_ DHPRI 521_ VKLYD 526_ YFSLD 531_ TDTFC 536_ TVLEY 541_ CEGND 546_ LDFYL 551_ KQHKL 556_ MSEKE 561_ ARSIV 566_ MQIVN 571_ ALRYL 576_ NEIKP 581_ PIIHY 586_ DLKPG 591_ NILLV 596_ DGTAC 601_ GEIKI 606_ TDFGL 611_ SKIMD 616_ DDSYG 621_ VDGMD 626_ LTSQG 631_ AGTYW 636_ YLPPE 641_ CFVVG 646_ KEPPK 651_ ISNKV 656_ DVWSV 661_ GVIFF 666_ QCLYG 671_ RKPFG 676_ HNQSQ 681_ QDILQ 686_ ENTIL 691_ KATEV 696_ QFPVK 701_ PVVSS 706_ EAKAF 711_ IRRCL 716_ AYRKE 721_ DRFDV 726_ HQLAN 731_ DPYLL 736_ PHMRR 741_ SNSSG 746_ NLHMA 751_ GLTAS 756_ PTPPS 761_SSIIT
1: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'