ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H)
1_MESQE 6_ PTESS 11_ QNGKQ 16_ YIISE 21_ ELISE 26_ GKWVK 31_ LEKTT 36_ YMDPT 41_ GKTRT 46_ WESVK 51_ RTTRK 56_ EQTAD 61_ GVAVI 66_ PVLQR 71_ TLHYE 76_ CIVLV 81_ KQFRP 86_ PMGGY 91_ CIEFP 96_ AGLID 101_ DGETP 106_ EAAAL 111_ RELEE 116_ ETGYK 121_ GDIAE 126_ CSPAV 131_ CMDPG 136_ LSNCT 141_ IHIVT 146_ VTING 151_ DDAEN 156_ ARPKP 161_ KPGDG 166_ EFVEV 171_ ISLPK 176_ NDLLQ 181_ RLDAL 186_ VAEEH 191_ LTVDA 196_ RVYSY 201_ ALALK 206_ HANAK 211_PFEVP
1: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:17052728, PubMed:19699693, PubMed:21389046). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity)